The Link Between Metabolism and Immunity

In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation. To better understand the role of Nucb2, a research […]

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Obesity and cancer risk: the role of the insulin–IGF axis

Accumulating epidemiological evidence shows that being either overweight or obese, in other words having excess body weight (EBW), is associated with an increased risk of several, common, adult cancers. The molecular mechanisms that underlie these associations are not understood fully, but insulin resistance is likely to be important. The insulin–cancer hypothesis postulates that chronic hyperinsulinemia is associated with decreased […]

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The Critical Importance of Time Restricted Feeding in Weight Loss

There have been two main changes in dietary habits from the 1970s (before the obesity epidemic) until today. First, there was the change is what we were recommended to eat. Prior to 1970, there was no official government sanctioned dietary advice. You ate what your mother told you to eat. With the publication of the […]

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Reverse engineered approach to human longevity

Dr. Peter Attia is a health speaker, researcher, nutrition and longevity expert, and the founder of Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. His practice applies nutrition science, lipidology, four-system endocrinology, sleep physiology, stress management, and exercise physiology to minimize the risk of chronic disease onset, […]

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Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents

The purpose for the study is to compare the effects of a low-carbohydrate (LC) diet with those of a low-fat (LF) diet on weight loss and serum lipids in overweight adolescents. The study is designed as a randomized, controlled 12-week trial. Random, nonblinded assignment of participants referred for weight management. The study group (LC) (n = […]

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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of […]

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We’re in a new age of obesity. How did it happen?

Hypotheses abound concerning the origins of the global obesity epidemic. Genetic predisposition, maternal obesity, excessive maternal weight gain, diabetes, tobacco use during pregnancy, and prenatal exposure to obesogens or endocrine disruptors have all been implicated. An international survey of more than 300 policymakers reported that more than 90% believed personal motivation was a strong or very […]

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Effects of Low-Carbohydrate and Low-Fat Diets

Low-carbohydrate diets are popular for weight loss, but their cardiovascular effects have not been well-studied, particularly in diverse populations. The objective of the study is to examine the effects of a low-carbohydrate diet compared with a low-fat diet on body weight and cardiovascular risk factors. In the study were involved 148 men and women without clinical […]

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Sleep deprivation: Impact on cognitive performance

Today, prolonged wakefulness is a widespread phenomenon. Nevertheless, in the field of sleep and wakefulness, several unanswered questions remain. Prolonged wakefulness can be due to acute total sleep deprivation (SD) or to chronic partial sleep restriction. Although the latter is more common in everyday life, the effects of total SD have been examined more thoroughly. […]

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