An Evolutionary and Mechanistic Perspective on Dietary Carbohydrate Restriction in Cancer Prevention

The confluence of basic cell biochemistry, epidemiological and anthropologic evidence points to high dietary carbohydrate and the associated disruption of the glucose-insulin axis as causes of the current increase in metabolic disorders, metabolic syndrome, hypertension and cardiovascular disease. This hyperinsulinemic state likely contributes, as well, to an increased mutagenic microenvironment, with increased risk for cancer. […]

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Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

Very-low-carbohydrate diets or ketogenic diets have been in use since the 1920s as a therapy for epilepsy and can, in some cases, completely remove the need for medication. From the 1960s onwards they have become widely known as one of the most common methods for obesity treatment. Recent work over the last decade or so […]

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Long-term effects of a ketogenic diet in obese patients

Although various studies have examined the short-term effects of a ketogenic diet in reducing weight in obese patients, its long-term effects on various physical and biochemical parameters are not known. To determine the effects of a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated […]

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Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. […]

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Link between diabetes and cancer risk firmly established

That diabetes and cancer are linked in some way is by no means a new idea, but it had never previously been confirmed. Now, a major new study draws a firm conclusion: diabetes raises a person’s risk of developing cancer. New research warns that the risk of cancer is sex-specific in people with diabetes, and […]

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Ketogenic Diet as a Metabolic Therapy for Mood Disorders

Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body […]

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Is Alzheimer’s Disease Actually Type 3 Diabetes?

For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well as the onset of eventual outward symptoms, of Alzheimer’s disease. The study was supported by the National Institute on Aging (NIA), part […]

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Heart attacks at strokes ‘set to soar 30% due to diabetes epidemic’

Patients with type 2 diabetes were two to four times more likely to have a heart attack or stroke, the British Heart Foundation said,  Heart attacks and strokes will rocket over the coming years as the diabetes epidemic sweeping the nation takes its toll, a charity has warned. The increase could be as high as […]

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Children as young as NINE suffering from diabetes as cases also soar among teens

Children as young as nine are being treated for type 2 diabetes in a devastating consequence of the obesity crisis. Doctors are reporting a surge in cases among children and teenagers – whereas 20 years ago the illness had only ever been seen in adults. A national audit shows the number of under-25s being treated for […]

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Starve Cancer Cells to Death By Removing Sugar From Your Diet

Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway in cancer cells that is dependent on the kinase RIPK1. Glucose withdrawal triggered rapid plasma […]

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