Dietary carbohydrates: role of quality and quantity in chronic disease

Would reduction in total carbohydrate intake (currently typically 45-65% of total energy) help control body weight in general population and susceptible subgroups? What is the role of a low carbohydrate diet in prevention and treatment of metabolic syndrome and type 2 diabetes, and in management of type 1 diabetes? Does ketosis induced by severe carbohydrate […]

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Dr. Berg Interviews Dr. Jason Fung on Intermittent Fasting & Losing Weight

Dr. Eric Berg interviews Dr. Jason Fung on intermittent fasting, obesity, diabetes and insulin. Dr. Fung discusses calories and how its not about the calories, it’s about the hormones, specifically insulin. Insulin makes you fat. Diets that lower calories fail repeatedly. The cause of obesity is too much insulin. Lowering your carbs and intermittent fasting. […]

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Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review

Vascular calcification, a cause of cardiovascular morbidity and mortality, is an actively regulated process involving vitamin K dependent proteins (VKDPs) among others. Vitamin K is an essential micronutrient, present in plants and animal fermented products that plays an important role as a cofactor for the post-translational γ-carboxylation of glutamic acid residues in a number of […]

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Juice Is Not Healthy

Obesity affects 40 percent of adults and 19 percent of children in the United States and accounts for more than $168 billion in health care spendingeach year. Sugary beverages are thought to be one of the major drivers of the obesity epidemic. These drinks (think soda and sports drinks) are the largest single source of added sugars for Americans and contribute, on […]

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The Carbohydrate-Insulin Model of Obesity Beyond “Calories In, Calories Out”

Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high–glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic […]

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Ketogenic diet may boost targeted cancer therapy

A very low carbohydrate, high-fat diet called the ketogenic diet may improve the effectiveness of an emerging class of cancer drugs, according to a study in mice by investigators at Weill Cornell Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian. In a study published in Nature on July 4, scientists provide a possible explanation for why the […]

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Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet

KD induces tissue-specific reprogramming of the circadian clock in liver and gut KD induces an increase in liver BMAL1 chromatin recruitment and amplitude of CCGs KD drives tissue-specific oscillation of PPARα and its target genes Oscillation of βOHB in gut and serum parallels gut-specific cycling of H3 acetylation   The circadian clock orchestrates rhythms in […]

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Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward

Fat and carbohydrate interact to potentiate reward independently of liking This is reflected in supra-additive responses in the striatum during food valuation Participants are able to estimate energy density from fat, but not carbohydrate Accurate estimation of energy density recruits a prefrontal-fusiform gyrus circuit Post-ingestive signals conveying information about the nutritive properties of food are […]

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Obesity is common, serious and costly

The prevalence of obesity was 39.8% and affected about 93.3 million of U.S. adults in 2015-2016. [Read CDC National Center for Health Statistics (NCHS) data brief PDF-603KB] Obesity-related conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. [Read guidelines] The estimated annual medical cost […]

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Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12-week study comparing two hypocaloric diets (approximately 1,500 kcal): a carbohydrate-restricted diet (CRD) (%carbohydrate:fat:protein = […]

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