Effects of A Low Carbohydrate Diet On Energy Expenditure During Weight Loss Maintenance

The objective of the study was to determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure. 164 adults aged 18-65 years with a body mass index of 25 or more participated to the study. After 12% (within 2%) weight loss on a run-in diet, participants were randomly assigned to […]

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A Staggering Number of Troops Are Fat and Tired, Report Says

A 2018 RAND report on health promotion and disease prevention has painted a grim picture of the military’s physical fitness and sleep standards. The study, featuring roughly 18,000 randomly selected participants across each of the service branches, showed that almost 66 percent of service members are considered to be either overweight or obese, based on the military’s […]

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New Research Suggests Link Between Diabetes and Brain Function

A study of older people in the UK suggests people with diabetes lose cognitive ability faster than people with normal blood sugar control. The findings, published in Diabetologia, was led by researchers at Imperial College London. They studied more than 5,000 people over the age of 50 and measured their cognitive decline over a 10 year […]

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The Straight Dope on Cholesterol

Cholesterol is one of the most misunderstood molecules in the human body. Much like fire, it can be an essential tool for life, if used properly, or a destructive force if allowed to run amok. In this presentation, Peter Attia will explain how the body creates, moves, and utilizes this vital molecule and how what […]

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Why Cholesterol is Good for You

Dr. Terry Wahls is a professor of medicine at the University of Iowa where she conducts clinical research on the use of diet and lifestyle to treat brain-related problems. She has also worked at the VA for many years in the traumatic brain injury clinic and was the director of the therapeutic lifestyle clinic. In […]

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What’s the Cause of Insulin Resistance?

Dr. Sarah Hallberg is a physician, board-certified lipidologist, Medical Director at Virta Health, Medical Director at the Indiana University Health Medical Weight Loss Program, and Executive Director at The Nutrition Coalition. She is the primary investigator on a recent clinical trial examining a technology-supported and medically-supervised ketogenic intervention that reverses type 2 diabetes and prediabetes.

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A Low-Carbohydrate, Ketogenic Diet to Treat Type 2 Diabetes

The low-carbohydrate, ketogenic diet (LCKD) may be effective for improving glycemia and reducing medications in patients with type 2 diabetes. From an outpatient clinic, we recruited 28 overweight participants with type 2 diabetes for a 16-week single-arm pilot diet intervention trial. We provided LCKD counseling, with an initial goal of <20 g carbohydrate/day, while reducing […]

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Breast Cancer Risk in Metabolically Healthy but Overweight Postmenopausal Women

Adiposity is an established risk factor for postmenopausal breast cancer. Recent data suggest that high insulin levels in overweight women may play a major role in this relationship, due to insulin’s mitogenic/antiapoptotic activity. However, whether overweight women who are metabolically healthy (i.e., normal insulin sensitivity) have elevated risk of breast cancer is unknown. We investigated […]

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Could A Ketogenic Diet Alleviate Gout?

More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in […]

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Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

Obesity results in a profound perturbation of the plasma metabolome At any given BMI, abnormal metabolomes associate with different health outcomes At any given BMI, different genetic obesity risks do not change the metabolome A metabolome signature effectively tracks changes in obesity Obesity is a heterogeneous phenotype that is crudely measured by body mass index […]

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