Inflammation, Nutritional Ketosis and Metabolic Disease

Metabolic syndrome is a cluster of conditions — increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels — that occur together, increasing your risk of heart disease, stroke and diabetes

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Prevalence of Optimal Metabolic Health in American Adults

Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. Data from the National Health and Nutrition Examination Survey […]

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Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention

This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Methods Children and adolescents with overweight or obesity (n = 920) and a population‐based control sample […]

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Estimation of Global Insulin Use for Type 2 Diabetes, 2018–30

The amount of insulin needed to effectively treat type 2 diabetes worldwide is unknown. It also remains unclear how alternative treatment algorithms would affect insulin use and disability-adjusted life-years (DALYs) averted by insulin use, given that current access to insulin (availability and affordability) in many areas is low. The aim of this study was to […]

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Taking Steps to Better Health

Besides cardiovascular health, the established physical benefits of walking at a moderate pace (about three miles per hour) include: Lessened cancer risk Reduced mental decline, including dementia Lowered chance of heart disease Improved joint function Stronger bones Reduced risk for diabetes Energy boost The benefits of walking extend to mental perks as well. Walking increases the release of […]

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Sitting Is The New Smoking

An alien visitor to our planet would be perplexed by modern human life, not least our relationship with physical exertion. After 6 million years of hunter-gatherer existence, humans can be observed sheltering in warm rooms, counteracting the tiresome effects of earth’s gravity by slouching on comfortable seats in front of glowing screens, being whisked effortlessly […]

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Neighborhoods and Obesity

This review critically summarizes the literature on neighborhood determinants of obesity and proposes a conceptual framework to guide future inquiry. Thirty-seven studies met all inclusion criteria and revealed that the influence of neighborhood-level factors appears mixed. Neighborhood-level measures of economic resources were associated with obesity in 15 studies, while the associations between neighborhood income inequality […]

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Brain Evolution, the Determinates of Food Choice, and the Omnivore’s Dilemma

A coevolutionary paradigm using a biocultural perspective can help to unravel the complex interactions that led to the contemporary pattern of eating. Evolutionary history helps to understand the adaptation of diet and its nutritional implications. Anatomical and behavioral changes linked to changing dietary patterns in the Paleolithic resulted in an adaptive framework that affects modern […]

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Obesity: From the Agricultural Revolution to the Contemporary Pediatric Epidemic

Obesity is pandemic in Western society. Currently, approximately 100 million Americans are overweight (body mass index > 25 kg/m2) or obese (body mass index > 30 kg/m2). The pandemic is largely attributable to the relatively recent (from an evolutionary perspective) adoption of a sedentary lifestyle, coupled with the high availability of foods with high caloric […]

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Obesity and Overweight

Key facts Worldwide obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults, 18 years and older, were overweight. Of these over 650 million were obese. 39% of adults aged 18 years and over were overweight in 2016, and 13% were obese. Most of the world’s population live in countries where overweight […]

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