Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy

The natural compound berberine has been reported to exhibit anti-diabetic activity and to improve disordered lipid metabolism. In our previous study, we found that such compounds upregulate expression of sirtuin 1—a key molecule in caloric restriction, it is, therefore, of great interest to examine the lipid-lowering activity of berberine in combination with a sirtuin 1 […]

Prevalence of Optimal Metabolic Health in American Adults

Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. Data from the National Health and Nutrition Examination Survey […]

Estimation of Global Insulin Use for Type 2 Diabetes, 2018–30

The amount of insulin needed to effectively treat type 2 diabetes worldwide is unknown. It also remains unclear how alternative treatment algorithms would affect insulin use and disability-adjusted life-years (DALYs) averted by insulin use, given that current access to insulin (availability and affordability) in many areas is low. The aim of this study was to […]

Association Between Obesity and Cardiovascular Outcomes

Do mendelian randomization data show that an association exists between obesity and cardiovascular outcomes? In this systematic review and meta-analysis of nearly 1 million participants, obesity was associated with type 2 diabetes and coronary artery disease but not with stroke. Obesity may increase the risk of subsequent diabetes and may contribute to cardiovascular outcomes and […]

Taking Steps to Better Health

Besides cardiovascular health, the established physical benefits of walking at a moderate pace (about three miles per hour) include: Lessened cancer risk Reduced mental decline, including dementia Lowered chance of heart disease Improved joint function Stronger bones Reduced risk for diabetes Energy boost The benefits of walking extend to mental perks as well. Walking increases the release of […]

Sitting Is The New Smoking

An alien visitor to our planet would be perplexed by modern human life, not least our relationship with physical exertion. After 6 million years of hunter-gatherer existence, humans can be observed sheltering in warm rooms, counteracting the tiresome effects of earth’s gravity by slouching on comfortable seats in front of glowing screens, being whisked effortlessly […]

Worldwide Obesity Dynamics and Their Determinants

Review of results of the study is focusing on large-scale surveys and nationally representative studies of diet, activity, and obesity among adults and children. The study was conducted with youth and adults from a range of countries around the world. Task Force guidelines for defining overweight and obesity are used for youth and the body […]

Neighborhoods and Obesity

This review critically summarizes the literature on neighborhood determinants of obesity and proposes a conceptual framework to guide future inquiry. Thirty-seven studies met all inclusion criteria and revealed that the influence of neighborhood-level factors appears mixed. Neighborhood-level measures of economic resources were associated with obesity in 15 studies, while the associations between neighborhood income inequality […]

Obesity: From the Agricultural Revolution to the Contemporary Pediatric Epidemic

Obesity is pandemic in Western society. Currently, approximately 100 million Americans are overweight (body mass index > 25 kg/m2) or obese (body mass index > 30 kg/m2). The pandemic is largely attributable to the relatively recent (from an evolutionary perspective) adoption of a sedentary lifestyle, coupled with the high availability of foods with high caloric […]

Costs of Foraging Predispose Animals to Obesity-Related Mortality when Food Is Constantly Abundant.

Obesity is an important medical problem affecting humans and animals in the developed world, but the evolutionary origins of the behaviours that cause obesity are poorly understood. The potential role of occasional gluts of food in determining fat-storage strategies for avoiding mortality have been overlooked, even though animals experienced such conditions in the recent evolutionary […]