Glucose Metabolism in Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral renal cyst formation. Publimed: Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Recent identification of signaling cascades deregulated in ADPKD has led to the initiation of several clinical trials, but an approved therapy is still lacking. Using a […]

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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. Springer Link: Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet We specifically tested the […]

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“Dirty Dozen” and “Clean Fifteen” Lists

The Environmental Working Group (EWG) recently released its 2017 “Dirty Dozen” and “Clean Fifteen” lists — a catalog of fruits and vegetables with the highest and lowest amounts of pesticide residue. Strawberries still top the “Dirty Dozen” list — in fact, one sample of strawberries had more than 20 different pesticides. The increased insect burden […]

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Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010

Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics. These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making. The Jama Network: Postmarket Safety Events Among Novel Therapeutics Approved by the US […]

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Reversal of Diabetic Nephropathy by a Ketogenic Diet

Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. PLOS: Reversal of Diabetic Nephropathy by a Ketogenic Diet Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged […]

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Diabetes is even deadlier than we thought

Nearly four times as many Americans may die of diabetes as indicated on death certificates, a rate that would bump the disease up from the seventh-leading cause of death to No. 3, according to estimates in a recent study. The Washington Post: Diabetes is even deadlier than we thought, study suggests Researchers and advocates say that […]

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Carb Loaded: A Culture Dying to Eat

The film traces the origins of our beliefs about healthful and unhealthful food. Experts from all over the world talk about the problems as well as short and long term solutions. Among the many experts in the film are authors like Gary Taubes, Mark Sisson, and Melanie Warner. Medical doctors such as David Perlmutter M.D., […]

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Americans Now Drink More Bottled Water

Annual sales of bottled water surpass soda in the U.S. for the first time ever. The Wall Street Journal: Soda Loses Its U.S. Crown: Americans Now Drink More Bottled Water  *Launched in 2017. Sources: Beverage Marketing Corp. (volume, consumption); Euromonitor International (retail sales) Americans now officially drink more bottled water than soda. It’s a shift […]

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Effect of fructose consumption on insulin sensitivity in nondiabetic subjects

High fructose consumption has been suggested to contribute to several features of metabolic syndrome including insulin resistance, but to our knowledge, no previous meta-analyses have investigated the effect of fructose on insulin sensitivity in nondiabetic subjects. We performed a systematic review and meta-analysis of controlled diet-intervention studies in nondiabetic subjects to determine the effect of […]

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