The Link Between Metabolism and Immunity

In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation. To better understand the role of Nucb2, a research […]

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An Update on Glucose Toxicity

Chronic exposure of glucose rich environment creates several physiological and pathophysiological changes. There are several pathways by which hyperglycemia exacerbate its toxic effect on cells, tissues and organ systems. Hyperglycemia can induce oxidative stress, upsurge polyol pathway, activate protein kinase C (PKC), enhance hexosamine biosynthetic pathway (HBP), promote the formation of advanced glycation end-products(AGEs) and finally alters gene expressions. Prolonged hyperglycemic condition leads to severe diabetic condition by […]

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Study finds people with type 2 diabetes at higher risk of death from both obesity-related and non-obesity related cancers

Being overweight or obese may put adults with diabetes at greater risk of dying from cancer than their diabetes-free counterparts, particularly for obesity-related cancers such as those arising from the bowel, kidney, and pancreas in men and women, and from the breast and endometrium (lining of the uterus) in women, according to a large observational […]

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Type 2 Diabetes: When Does It Start?

Data from 27,392 nondiabetic health examinees were retrospectively analyzed for a mean of 5.3 years. Trajectories of fasting plasma glucose (FPG), body mass index (BMI), and the single point insulin sensitivity (Si) estimator (SPISE), an index of Si, 10 years before diagnosis of prediabetes (PDM; n = 4781) or diabetes (n = 1061) were separately […]

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Why Butter Is Better

When the fabricated food folks and apologists for the corporate farm realized that they couldn’t block America’s growing interest in diet and nutrition, a movement that would ultimately put an end to America’s biggest and most monopolistic industries, they infiltrated the movement and put a few sinister twists on information going out to the public. […]

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The Critical Importance of Time Restricted Feeding in Weight Loss

There have been two main changes in dietary habits from the 1970s (before the obesity epidemic) until today. First, there was the change is what we were recommended to eat. Prior to 1970, there was no official government sanctioned dietary advice. You ate what your mother told you to eat. With the publication of the […]

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The Toll of America’s Obesity

Beyond the human suffering, diet-related diseases impose massive economic costs. Obesity rates in the United States continue to worsen. So, too, does economic inequality. Are these trends related? After remaining essentially flat in the 1950s and 1960s, the prevalence of obesity doubled in adults and tripled in children between the 1970s and 2000. According to new data from the Centers […]

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Reverse engineered approach to human longevity

Dr. Peter Attia is a health speaker, researcher, nutrition and longevity expert, and the founder of Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. His practice applies nutrition science, lipidology, four-system endocrinology, sleep physiology, stress management, and exercise physiology to minimize the risk of chronic disease onset, […]

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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer

Tumor patients exhibit an increased peripheral demand of fatty acids and protein. Contrarily, tumors utilize glucose as their main source of energy supply. Thus, a diet supplying the cancer patient with sufficient fat and protein for his demands while restricting the carbohydrates (CHO) tumors thrive on, could be a helpful strategy in improving the patients’ […]

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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of […]

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