Association Between Obesity and Cardiovascular Outcomes

Do mendelian randomization data show that an association exists between obesity and cardiovascular outcomes? In this systematic review and meta-analysis of nearly 1 million participants, obesity was associated with type 2 diabetes and coronary artery disease but not with stroke. Obesity may increase the risk of subsequent diabetes and may contribute to cardiovascular outcomes and […]

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Sitting Is The New Smoking

An alien visitor to our planet would be perplexed by modern human life, not least our relationship with physical exertion. After 6 million years of hunter-gatherer existence, humans can be observed sheltering in warm rooms, counteracting the tiresome effects of earth’s gravity by slouching on comfortable seats in front of glowing screens, being whisked effortlessly […]

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Neighborhoods and Obesity

This review critically summarizes the literature on neighborhood determinants of obesity and proposes a conceptual framework to guide future inquiry. Thirty-seven studies met all inclusion criteria and revealed that the influence of neighborhood-level factors appears mixed. Neighborhood-level measures of economic resources were associated with obesity in 15 studies, while the associations between neighborhood income inequality […]

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Brain Evolution, the Determinates of Food Choice, and the Omnivore’s Dilemma

A coevolutionary paradigm using a biocultural perspective can help to unravel the complex interactions that led to the contemporary pattern of eating. Evolutionary history helps to understand the adaptation of diet and its nutritional implications. Anatomical and behavioral changes linked to changing dietary patterns in the Paleolithic resulted in an adaptive framework that affects modern […]

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Effects of a Low Carbohydrate Diet on Energy Expenditure During Weight Loss Maintenancel

Objective  of the study was to determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure. The study was done with a multicenter collaboration at US two sites, August 2014 to May 2017.  164 adults aged 18-65 years with a body mass index of 25 or more participated to the study After 12% […]

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The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out”.

Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high-glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic […]

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Dr. David Perlmutter on the Link Between Sugar and Alzheimer’s Disease

As noted by Perlmutter, even though there’s no conventional treatment for Alzheimer’s, research shows this devastating degenerative neurological disease can be effectively prevented by lowering sugar exposure, increasing exercise and improving the quality of your sleep. “The science is now completely lined up behind us, showing that our dietary choices are having a huge influence on the […]

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Emotional Eating Is Learned Not Inherited

Emotional over‐eating (EOE) and emotional under‐eating (EUE) are common behaviours that develop in early childhood and are hypothesised to play a role in weight status. Data from a British twin cohort demonstrated that environmental, rather than genetic, factors shape individual differences in both behaviours in early childhood. The aim of this current study was to […]

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Effect of A Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients With Type 2 Diabetes

It is not known how a low-carbohydrate, high-protein, high-fat diet causes weight loss or how it affects blood glucose levels in patients with type 2 diabetes. OBJECTIVE: To determine effects of a strict low-carbohydrate diet on body weight, body water, energy intake and expenditure, glycemic control, insulin sensitivity, and lipid levels in obese patients with type […]

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Dietary Carbohydrates Impair Healthspan and Promote Mortality

It has been known since the 1930s that global reduction of food uptake, so-called calorie restriction, extends the lifespan of rodents, other model organisms, including rhesus monkeys, and possibly humans due to an interacting set of experimentally established mechanisms. By contrast and based on observational coincidence rather than prospective causality, dietary recommendations to maintain human health have […]

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