Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress

Highlights Early time-restricted feeding (eTRF) increases insulin sensitivity eTRF also improves β cell function and lowers blood pressure and oxidative stress eTRF lowers the desire to eat in the evening, which may facilitate weight loss Intermittent fasting can improve health even in the absence of weight loss Intermittent fasting (IF) improves cardiometabolic health; however, it […]

Read More »

Fructose and Cardiometabolic Health

Recent attention has focused on fructose as having a unique role in the pathogenesis of cardiometabolic diseases. However, because we rarely consume fructose in isolation, the major source of fructose in the diet comes from fructose-containing sugars, sucrose and high fructose corn syrup, in sugar-sweetened beverages and foods. Intake of sugar-sweetened beverages has been consistently […]

Read More »

Dietary Restriction Increases Lifespan

Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated with a loss of mitochondrial network homeostasis, but cellular processes causally linking these changes to organismal senescence remain unclear. Here, we show that AMP-activated protein kinase (AMPK) and dietary restriction (DR) promote longevity in C. elegans via maintaining […]

Read More »

Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet

• KD induces tissue-specific reprogramming of the circadian clock in liver and gut • KD induces an increase in liver BMAL1 chromatin recruitment and amplitude of CCGs • KD drives tissue-specific oscillation of PPARα and its target genes • Oscillation of βOHB in gut and serum parallels gut-specific cycling of H3 acetylation The circadian clock […]

Read More »

Mitochondria: The Ketogenic Diet—A Metabolism-Based Therapy

Mitochondria are the energy-producing organelles of the cell, generating ATP via oxidative phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose. Ketone bodies generated by fatty acid oxidation can serve as alternative metabolites for aerobic energy production. The ketogenic diet, which is high in fat and low in carbohydrates, mimics the metabolic state […]

Read More »

What Will Happen to Your Body If You Walk Every Day

Walking is a totally free, easy exercise that requires little effort, and benefits not only your physical but also your mental well-being. If you’re looking for a simple yet very effective way of losing weight and improving your overall health, walking is something just for you. People who are physically active throughout their life are […]

Read More »

Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet

New research findings published in the journal PEDIATRICS reveal the power of a very low carb diet to normalize blood sugars for t1 diabetics of all ages with no negative consequences  The study evaluated glycemic control among children and adults with type 1 diabetes mellitus (T1DM) who consume a very low–carbohydrate diet (VLCD). The authors conducted […]

Read More »

The Ketogenic Diet for Type II Bipolar Disorder

Successful mood stabilizing treatments reduce intracellular sodium in an activity-dependent manner. This can also be achieved with acidification of the blood, as is the case with the ketogenic diet. Two women with type II bipolar disorder were able to maintain ketosis for prolonged periods of time (2 and 3 years, respectively). Both experienced mood stabilization […]

Read More »

The Role for Ketogenic Diets in Epilepsy

Highlights • Ketogenic diets offer adjunctive therapy for chronic epilepsy and refractory status epilepticus. • Studies support feasibility and efficacy of the classic ketogenic diet and its variants in adults. • Potential complications and side effects of diet therapy are often preventable and manageable. • Strategies are needed to improve diet adherence. Abstract Ketogenic diet (KD) therapies are high fat, low carbohydrate […]

Read More »