Yale-led study finds surprise link between metabolism and immunity

In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation. To better understand the role of Nucb2, a research […]

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Two Type 2 Diabetes Drugs Linked to Higher Risk of Heart Disease

Are second-line antidiabetic medications (ADMs) associated with cardiovascular events among insured adult patients with type 2 diabetes who are initiating second-line therapy? This cohort study of 132 737 adults with type 2 diabetes found that glucagon-like peptide 1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium-glucose cotransporter 2 inhibitors were associated with similar cardiovascular outcomes. Sulfonylureas […]

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Inflammation, Nutritional Ketosis and Metabolic Disease

Metabolic syndrome is a cluster of conditions — increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels — that occur together, increasing your risk of heart disease, stroke and diabetes

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‘Therapeutic Fasting – Solving the Two-Compartment Problem’

Intermittent fasting is the ancient secret of health. It is ancient because it has been practiced throughout all of human history. It’s a secret because this powerful habit has been virtually forgotten. But now many people are re-discovering this dietary intervention. It can carry huge benefits if it is done right: weight loss, increased energy, […]

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Deaths Attributable to Diabetes in the United States: Comparison of Data Sources and Estimation Approaches

We estimated population attributable fractions (PAF) for cohorts aged 30–84 who were surveyed in the National Health Interview Survey (NHIS) between 1997 and 2009 (N = 282,322) and in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2010 (N = 21,814). Cohort members were followed prospectively for mortality through 2011. We identified […]

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The Pathways of Insulin Resistance: Exposure and Implications

Ivor Cummins originally completed a Chemical Engineering degree in 1990 (Biochemical Stream, BE(Chem) CEng MIEI), followed by over 25 years in corporate technical leadership and management positions. Ivor’s particular specialty was leading teams in complex problem-solving scenarios. Following less-than-ideal blood test results, he was unable to get solutions from the doctors he consulted. He thus […]

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What if sugar is worse than just empty calories?

Discussions about the global epidemics of obesity and type 2 diabetes tend to assume that these are new phenomena, products of changes in the way we eat and live that go back perhaps 50 years. For some populations with diets and lifestyles that are only recently westernised that may be true. In the United States, […]

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Diabetes is linked with cognitive dysfunction

Middle-aged adults with diabetes performed worse on assessments of executive function, attention and memory when compared with adults without diabetes, independent of other cardiovascular risk factors and depression status, according to findings from a population-based study. “Recently, attention has been given to modifiable risk factors to help curtail the increasing prevalence of dementia, and several […]

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Two Type 2 diabetes drugs linked to higher risk of heart disease

Are second-line antidiabetic medications (ADMs) associated with cardiovascular events among insured adult patients with type 2 diabetes who are initiating second-line therapy? This cohort study of 132 737 adults with type 2 diabetes found that glucagon-like peptide 1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium-glucose cotransporter 2 inhibitors were associated with similar cardiovascular outcomes. Sulfonylureas […]

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High Carbohydrate Foods Can Raise Risk For Heart Problems

“Looking inside” the arteries of students eating a variety of foods, Dr. Michael Shechter of Tel Aviv University’s Sackler School of Medicine and the Heart Institute of Sheba Medical Center — with collaboration of the Endocrinology Institute — visualized exactly what happens inside the body when the wrong foods for a healthy heart are eaten. […]

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