Breast Cancer Risk in Metabolically Healthy but Overweight Postmenopausal Women

Adiposity is an established risk factor for postmenopausal breast cancer. Recent data suggest that high insulin levels in overweight women may play a major role in this relationship, due to insulin’s mitogenic/antiapoptotic activity. However, whether overweight women who are metabolically healthy (i.e., normal insulin sensitivity) have elevated risk of breast cancer is unknown. We investigated […]

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Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

Obesity results in a profound perturbation of the plasma metabolome At any given BMI, abnormal metabolomes associate with different health outcomes At any given BMI, different genetic obesity risks do not change the metabolome A metabolome signature effectively tracks changes in obesity Obesity is a heterogeneous phenotype that is crudely measured by body mass index […]

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Does Fat Really Burn in the Flame of Carbohydrate?

Dr. Michael R. Eades received his BSCE degree in Civil Engineering from California Polytechnic University (Cal Poly), Pamona, California and his MD from the University of Arkansas Medical Sciences (UAMS). After completing training in General Surgery as UAMS, Dr. Eades (along with his wife) founded Medi-Stat Medical Clinics, a chain of general family medicine outpatient […]

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An Engineering View of Modern Chronic Disease Prevention

Ivor Cummins BE(Chem) CEng MIEI PMP® completed a Chemical Engineering degree at UCD in 1990. He has since spent over 25 years in corporate technical leadership and management positions, and was shortlisted in 2015 as one of the top 6 of 500 applicants for “Irish Chartered Engineer of the Year”. Ivor’s focus and specialty is […]

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Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia

Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. To model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free […]

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Metabolic Syndrome Highly Prevalent Even in Very Young Kids

Over 25% of 6-year-olds had at least one risk factor in study Over a quarter of young children in a study had abnormal metabolic profiles, researchers reported. In a cohort of 212 Swedish children around 6 years old, 26% possessed at least one of the criteria for metabolic syndrome — including hypertension, dyslipidemia, insulin resistance, […]

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Forecasting Life Expectancy

Understanding potential trajectories in health and drivers of health is crucial to guiding long-term investments and policy implementation. Past work on forecasting has provided an incomplete landscape of future health scenarios, highlighting a need for a more robust modelling platform from which policy options and potential health trajectories can be assessed. This study provides a […]

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Cellular recycling process is key to longer, healthier life

Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy – the process a cell uses […]

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