The Link Between Metabolism and Immunity

In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation. To better understand the role of Nucb2, a research […]

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An Update on Glucose Toxicity

Chronic exposure of glucose rich environment creates several physiological and pathophysiological changes. There are several pathways by which hyperglycemia exacerbate its toxic effect on cells, tissues and organ systems. Hyperglycemia can induce oxidative stress, upsurge polyol pathway, activate protein kinase C (PKC), enhance hexosamine biosynthetic pathway (HBP), promote the formation of advanced glycation end-products(AGEs) and finally alters gene expressions. Prolonged hyperglycemic condition leads to severe diabetic condition by […]

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Obesity and cancer risk: the role of the insulin–IGF axis

Accumulating epidemiological evidence shows that being either overweight or obese, in other words having excess body weight (EBW), is associated with an increased risk of several, common, adult cancers. The molecular mechanisms that underlie these associations are not understood fully, but insulin resistance is likely to be important. The insulin–cancer hypothesis postulates that chronic hyperinsulinemia is associated with decreased […]

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Why Butter Is Better

When the fabricated food folks and apologists for the corporate farm realized that they couldn’t block America’s growing interest in diet and nutrition, a movement that would ultimately put an end to America’s biggest and most monopolistic industries, they infiltrated the movement and put a few sinister twists on information going out to the public. […]

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Reverse engineered approach to human longevity

Dr. Peter Attia is a health speaker, researcher, nutrition and longevity expert, and the founder of Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. His practice applies nutrition science, lipidology, four-system endocrinology, sleep physiology, stress management, and exercise physiology to minimize the risk of chronic disease onset, […]

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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer

Tumor patients exhibit an increased peripheral demand of fatty acids and protein. Contrarily, tumors utilize glucose as their main source of energy supply. Thus, a diet supplying the cancer patient with sufficient fat and protein for his demands while restricting the carbohydrates (CHO) tumors thrive on, could be a helpful strategy in improving the patients’ […]

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Keto Diet May Increase Memory, Reduce Mortality

Two new studies, both conducted in mice, support each other’s findings: that the ketogenic, or “keto,” diet may improve memory in old age as well as prolong lifespan. The ketogenic diet, which is more commonly known as the keto diet, aims to reduce carbohydrate intake in favor of consuming more fat and sufficient protein. Recently, this diet type […]

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Benefits of Ketogenic Diet for Management of Type Two Diabetes: A Review

The prevalence of type two diabetes (T2D) has been increasing sharply worldwide. Many recent studies have been done to determine the effective strategies for better management of type two diabetes. One of these strategies was the Ketogenic Diet, which when performed on rats and human showed very impressive results. The benefits of having some ketone […]

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Ketogenic Diet Reduces Central Obesity

The glycolytic nature of cancer cells presents a potential treatment target that may be addressed by a ketogenic diet (KD). We hypothesized that a KD would improve body composition and lower serum insulin and insulin-like growth factor-I (IGF-I) in women with ovarian or endometrial cancer. In this randomized controlled trial, women with ovarian or endometrial […]

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An Evolutionary and Mechanistic Perspective on Dietary Carbohydrate Restriction in Cancer Prevention

The confluence of basic cell biochemistry, epidemiological and anthropologic evidence points to high dietary carbohydrate and the associated disruption of the glucose-insulin axis as causes of the current increase in metabolic disorders, metabolic syndrome, hypertension and cardiovascular disease. This hyperinsulinemic state likely contributes, as well, to an increased mutagenic microenvironment, with increased risk for cancer. […]

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