Coffee, Caffeine, and Health Outcomes: An Umbrella Review

To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, […]

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Taking Steps to Better Health

Besides cardiovascular health, the established physical benefits of walking at a moderate pace (about three miles per hour) include: Lessened cancer risk Reduced mental decline, including dementia Lowered chance of heart disease Improved joint function Stronger bones Reduced risk for diabetes Energy boost The benefits of walking extend to mental perks as well. Walking increases the release of […]

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Dietary Carbohydrates Impair Healthspan and Promote Mortality

It has been known since the 1930s that global reduction of food uptake, so-called calorie restriction, extends the lifespan of rodents, other model organisms, including rhesus monkeys, and possibly humans due to an interacting set of experimentally established mechanisms. By contrast and based on observational coincidence rather than prospective causality, dietary recommendations to maintain human health have […]

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Translating the Basic Science of Nutritional Ketosis & Keto-Adaptation

An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their […]

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All The Ways You’re Sabotaging Your Health by Overdoing It On Sugar

Sugar lurks in dozens of unsuspecting foods, from yogurts and salad dressings to juices and sauces. Even when sucrose — the popular form of table sugar is not present in a food item, sugar’s cousins fructose and dextrose can likely be found somewhere on the label. To truly avoid sugar, you’d also have to cut out simple carbohydrates, including the ones […]

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Kids See Thousands of Ads for Unhealthy Foods on Social Media

early three quarters of Canadian children are exposed to food marketing while using popular social media apps, a new study from the University of Ottawa found. The study, commissioned by Heart & Stroke, found that children see an estimated 111 advertisements for food per week, or an average of 5,772 ads per year on apps such as […]

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America’s Obesity Crisis

This study calculates the prevalence and economic effects of diseases related to obesity and overweight in the United States. These costs are paid by individuals and their households, employers, government, and society. The prevalence of obesity in the U.S. population has increased steadily since the 1960s—from 3.4 percent of adults in 1962 to 39.8 percent […]

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The Toll of America’s Obesity

Beyond the human suffering, diet-related diseases impose massive economic costs. Obesity rates in the United States continue to worsen. So, too, does economic inequality. Are these trends related? After remaining essentially flat in the 1950s and 1960s, the prevalence of obesity doubled in adults and tripled in children between the 1970s and 2000. According to new data from the Centers […]

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Breast Cancer Risk in Metabolically Healthy but Overweight Postmenopausal Women

Adiposity is an established risk factor for postmenopausal breast cancer. Recent data suggest that high insulin levels in overweight women may play a major role in this relationship, due to insulin’s mitogenic/antiapoptotic activity. However, whether overweight women who are metabolically healthy (i.e., normal insulin sensitivity) have elevated risk of breast cancer is unknown. We investigated […]

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Carbotoxicity

Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as “carbotoxicity.” Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as […]

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