The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m2 and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of […]

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Added Sugars Drive Nutrient and Energy Deficit in Obesity

Obesity has traditionally been thought of as a state of caloric imbalance, where the intake of calories exceeds the expenditure or ‘burning’ of calories. However, a more nuanced appreciation for the complex biochemistry and physiology of cellular energy generation suggests that obesity is a state of hormonal imbalance causing increased shunting of food energy into […]

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Consumption of Whole Eggs Promotes Greater Stimulation of Postexercise Muscle

Protein in the diet is commonly ingested from whole foods that contain various macro- and micronutrients. However, the effect of consuming protein within its natural whole-food matrix on postprandial protein metabolism remains understudied in humans. OWe aimed to compare the whole-body and muscle protein metabolic responses after the consumption of whole eggs with egg whites […]

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Genetically Determined Favourable Adiposity is Characterized by Lower Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such “favourable adiposity” alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined magnetic resonance imaging (MRI) data with genome-wide association […]

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Midlife Hypertension and 20-Year Cognitive Change

Hypertension is a treatable potential cause of cognitive decline and dementia, but its greatest influence on cognition may occur in middle age. The objective of the study was to evaluate the association between midlife (48-67 years of age) hypertension and the 20-year change in cognitive performance. The Atherosclerosis Risk in Communities cohort (1990-1992 through 2011-2013) […]

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KetoNutrition: From Science to Application

An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their […]

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Diabetes and Obesity Still on the Rise

A new report on the continued alarming rise of diabetes in the U.S. illustrates how decades of government dietary guidance has thus far failed to contain this costly and debilitating disease. As part of their State of American Well-Being series, Gallup and Sharecare found that 11.5% of the U.S. adult population was diagnosed with type […]

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Ultra-Processed Foods and Added Sugars in the US Diet

The purpose of the study is to investigate the contribution of ultra-processed foods to the intake of added sugars in the USA. Ultra-processed foods were defined as industrial formulations which, besides salt, sugar, oils and fats, include substances not used in culinary preparations, in particular additives used to imitate sensorial qualities of minimally processed foods […]

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