Targeting Cancer Cell Metabolism

Cancer cells are hungry. To feed their rapid growth and division, their metabolism changes. Moreover, they use sugar (glucose) in a different way to normal cells. This animation, created by Nature Reviews Drug Discovery, explores the key aspects of the altered metabolism in cancer cells and explains how these can be exploited for the development […]

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Isocaloric Fructose Restriction and Metabolic Improvement in Obese Children

Dietary fructose is implicated in metabolic syndrome, but intervention studies are confounded by positive caloric balance, changes in adiposity, or artifactually high amounts. This study determined whether isocaloric substitution of starch for sugar would improve metabolic parameters in Latino (n = 27) and African-American (n = 16) children with obesity and metabolic syndrome. Wiley Online Library: Isocaloric fructose restriction and […]

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Reduction of Risk for Cardiovascular Disease in Children and Adolescents

It is clear that risk factors for atherosclerotic CVD can develop during childhood and adolescence. This results from both genetic and environmental factors. When risk factors develop at an early age, they are likely to track over time, maintaining a high-risk status. This tracking is reinforced by ongoing and new adverse health behaviors. Professional Heart […]

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The Cholesterol and Calorie Hypotheses Are Both Dead

Emerging evidence shows that insulin resistance is the most important predictor of cardiovascular disease and type 2 diabetes. The Pharmaceutical Journal: The cholesterol and calorie hypotheses are both dead — it is time to focus on the real culprit: insulin resistance Aggressive lowering of low-density lipoprotein cholesterol (LDL-C) has been the cornerstone of preventative cardiology for decades. Statins […]

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Too Much Sugar Could Increase Depression Risk in Men

Men who consume a lot of added sugar in drinks, cakes and confectionery run an increased risk of depression, according to a new study. The Guardian: Too much sugar could increase depression risk in men, study suggests Researchers from University College London (UCL) looked at sugar in the diet and common mental health problems in a […]

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High Fructose Corn Syrup Has Been Quietly, Deceitfully Renamed

High fructose corn syrup is a killer. Since humans started consuming it, obesity rates have more than tripled and diabetes incidence has increased more than seven fold. Even when used in moderation it is a major cause of heart disease, obesity, cancer, dementia, liver failure, tooth decay, and more. So what does the FDA do about this silent […]

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Ketogenic Diets for Psychiatric Disorders

If you have a brain, you need to know about ketogenic diets. The fact that these specially-formulated low-carbohydrate diets have the power to stop seizures in their tracks is concrete evidence that food has a tremendous impact on brain chemistry and should inspire curiosity about how they work. I first became interested in ketogenic diets as […]

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Health Benefits of Nut Consumption

Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. PMC: Health Benefits of Nut Consumption Epidemiologic studies have associated nut consumption […]

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Impact of Nutrition on Social Decision Making

Food intake is essential for survival in all species for meeting energetic demands. PNAS: Impact of nutrition on social decision making However, food intake also modulates various biochemical processes underlying cognition. Across two studies, we showed that different macronutrient compositions in standard European meals affect plasma neurotransmitter precursor levels, and these in turn influence social decision […]

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