According to the modified ‘response to injury’ hypothesis of atherogenesis, there are at least two pathways leading to the inflammatory and proliferative lesions of the arterial intima. The first involves monocyte and platelet interaction induced by hypercholesterolaemia. The second pathway involves direct stimulation of the endothelium by a number of factors, including smoking, the metabolic consequences […]
Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles […]
Prolonged fasting downregulates a IGF-1/PKA pathway in stem Prolong fasting protects hematopoietic cells from chemotoxicity Prolonged fasting cycles promote HSC self-renewal to reverse immunosuppression Inhibition of IGF-1 or PKA signaling mimics the effects of prolonged Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting […]
Dr. Michael R. Eades received his BSCE degree in Civil Engineering from California Polytechnic University (Cal Poly), Pamona, California and his MD from the University of Arkansas Medical Sciences (UAMS). After completing training in General Surgery as UAMS, Dr. Eades (along with his wife) founded Medi-Stat Medical Clinics, a chain of general family medicine outpatient […]
Dr. Peter Attia discusses the history behind our beliefs about fat and cholesterol’s effects on our body systems and uses data to debunk myths.
David Unwin, Fellow of the Royal College of General Practitioners (FRCGP), and Senior Partner of the Norwood Surgery presented “Real life experiences: Weighing up the pros and cons of drugs and lifestyle choices properly before making choices” at the Swiss Re Institute’s Expert Forum on diabetes, Rüschlikon, 9 – 10 October 2017.
Hypertension is the second biggest known global risk factor for disease after poor diet; perhaps lifestyle interventions are underutilized? In a previous small pilot study, it was found that a low carbohydrate diet was associated with significant improvements in blood pressure, weight, ‘deprescribing’ of medications and lipid profiles. We were interested to investigate if these […]
Erynn Kay graduated from Northern Arizona University in 2005 with a Bachelors of Science in Microbiology. She then went on to earn a Masters of Medical Science in Physician Assistant Studies at Midwestern University in Glendale, Arizona in 2009. Erynn is a board certified, licensed Physician Assistant who works along side Dr. Jeffry Gerber (Denver’s […]
Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. Here we attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains—the world’s most abundant […]
The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet. The diet forces the body to burn fats rather than carbohydrates.