Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure

Exercise is a common component of weight loss strategies, yet exercise programs are associated with surprisingly small changes in body weight. This may be due in part to compensatory adaptations, in which calories expended during exercise are counteracted by decreases in other aspects of energy expenditure. Current Biology: Increases in Physical Activity Result in Diminishing […]

Read More »

Hyperinsulinemia in Obesity

Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and conversely, dietary and pharmacological manipulations that reduce insulin have occasionally been reported to cause weight loss. Society of Endocrinology: A causal role for hyperinsulinemia in obesity However, the causal role of insulin hypersecretion […]

Read More »

If Sugar Is Harmless, Prove It

Over the past half-century, the rate of obesity in America has nearly tripled, while the incidence of diabetes has increased roughly sevenfold. It’s estimated that the direct health care costs related to obesity and diabetes in the United States is $1 billion a day, while economists have calculated the indirect costs to society of these […]

Read More »

Gary Taubes ‘The Case Against Sugar’

Sugar is being called the new tobacco. Recent revelations exposed the sugar industry’s backroom cover-up of the harmful effects of this pervasive ingredient. Decades ago scientists were paid thousands of dollars to mislead the public into believing that fat should be avoided, when in fact, sugar causes a multitude of health problems and behavioral issues. […]

Read More »

Association of Body Mass Index with DNA

over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the Framingham Heart Study and the Lothian Birth Cohorts, with independent replication in three external cohorts of 4,055 participants. PLOS Medicine: Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian […]

Read More »

Obesity, adiposity, and dyslipidemia

The term ‘‘fat’’ may refer to lipids as well as the cells and tissue that store lipid (ie, adipocytes and adipose tissue). ‘‘Lipid’’ is derived from ‘‘lipos,’’ which refers to animal fat or vegetable oil. Adiposity refers to body fat and is derived from ‘‘adipo,’’ referring to fat. Adipocytes and adipose tissue store the greatest […]

Read More »