Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance

Study is based on 64 adults aged 18-65 years adults, with a body mass index of 25 or more. IAfter 12% (within 2%) weight loss on a run-in diet, participants were randomly assigned to one of three test diets according to carbohydrate content (high, 60%, n=54; moderate, 40%, n=53; or low, 20%, n=57) for 20 […]

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Two Type 2 Diabetes Drugs Linked to Higher Risk of Heart Disease

Are second-line antidiabetic medications (ADMs) associated with cardiovascular events among insured adult patients with type 2 diabetes who are initiating second-line therapy? This cohort study of 132 737 adults with type 2 diabetes found that glucagon-like peptide 1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium-glucose cotransporter 2 inhibitors were associated with similar cardiovascular outcomes. Sulfonylureas […]

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Inflammation, Nutritional Ketosis and Metabolic Disease

Metabolic syndrome is a cluster of conditions — increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels — that occur together, increasing your risk of heart disease, stroke and diabetes

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‘Therapeutic Fasting – Solving the Two-Compartment Problem’

Intermittent fasting is the ancient secret of health. It is ancient because it has been practiced throughout all of human history. It’s a secret because this powerful habit has been virtually forgotten. But now many people are re-discovering this dietary intervention. It can carry huge benefits if it is done right: weight loss, increased energy, […]

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Deaths Attributable to Diabetes in the United States: Comparison of Data Sources and Estimation Approaches

We estimated population attributable fractions (PAF) for cohorts aged 30–84 who were surveyed in the National Health Interview Survey (NHIS) between 1997 and 2009 (N = 282,322) and in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2010 (N = 21,814). Cohort members were followed prospectively for mortality through 2011. We identified […]

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A Ketogenic Diet Improves Cognition

Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns of dysfunction in advanced age. Because higher cognitive functions require large-scale interactions […]

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The Pathways of Insulin Resistance: Exposure and Implications

Ivor Cummins originally completed a Chemical Engineering degree in 1990 (Biochemical Stream, BE(Chem) CEng MIEI), followed by over 25 years in corporate technical leadership and management positions. Ivor’s particular specialty was leading teams in complex problem-solving scenarios. Following less-than-ideal blood test results, he was unable to get solutions from the doctors he consulted. He thus […]

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Sugar’s Sick Secrets

Walk into any grocery store, grab a few packaged products, and flip to the ingredients. You’ll likely spot added sugars  –  lots of them  –  provided you can discern their dizzying array of names: sucrose, dextrose, barley malt, agave nectar, high-fructose corn syrup, treacle, to list just a few. Why is our food saturated with […]

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