Ketogenic Diet Shows Promising Results for All Dementia Stages

Studies show a ketogenic diet can slow and even reverse symptoms of memory loss and cognitive impairment throughout all the dementia stages. You might be asking, “What is a ketogenic diet?” A ketogenic diet is a high-fat, adequate-protein, and low-carbohydrate diet that produces ketones—compounds the body can use to produce energy. Ketones have been shown in studies […]

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Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia

Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. OTo model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free […]

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Coffee, Caffeine, and Health Outcomes: An Umbrella Review

To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, […]

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Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy

The natural compound berberine has been reported to exhibit anti-diabetic activity and to improve disordered lipid metabolism. In our previous study, we found that such compounds upregulate expression of sirtuin 1—a key molecule in caloric restriction, it is, therefore, of great interest to examine the lipid-lowering activity of berberine in combination with a sirtuin 1 […]

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AMA advocates for transparency in food labeling and packaging

The American Medical Association (AMA) adopted new policy today aimed at increasing consumer awareness of the amount of added sugars, as well as the type of allergens, in food products. Specifically, the AMA is urging the U.S. Food and Drug Administration (FDA) to develop front-of-package warning labels for foods that are high in added sugars […]

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Prevalence of Optimal Metabolic Health in American Adults

Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. Data from the National Health and Nutrition Examination Survey […]

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Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention

This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Methods Children and adolescents with overweight or obesity (n = 920) and a population‐based control sample […]

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Care and Feeding of the Endocannabinoid System

The “classic” endocannabinoid (eCB) system includes the cannabinoid receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes. An emerging literature documents the “eCB deficiency syndrome” as an etiology in migraine, fibromyalgia, irritable bowel syndrome, psychological disorders, and other conditions. We performed a systematic review of clinical interventions that enhance […]

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