Effects of A Low Carbohydrate Diet on Energy Expenditure During Weight Loss Maintenance

The objective of the study was to determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure, and it was a multicenter collaboration at US two sites, from August 2014 to May 2017, and involved 164 adults aged 18-65 years with a body mass index of 25 or more. After […]

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The Carbohydrate-Insulin Model of Obesity

Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high-glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic […]

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Fiber Is Good for You

A diet of fiber-rich foods, such as fruits and vegetables, reduces the risk of developing diabetes, heart disease and arthritis. Indeed, the evidence for fiber’s benefits extends beyond any particular ailment: Eating more fiber seems to lower people’s mortality rate, whatever the cause. That’s why experts are always saying how good dietary fiber is for us. But while the benefits […]

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To Fight Fatty Liver, Avoid Sugary Foods and Drinks

Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction of sugary foods and beverages is a plausible treatment. In this randomized clinical trial that included 40 adolescent boys aged 11 to 16 years with nonalcoholic fatty liver disease followed up for 8 weeks, provision of a […]

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The race to cure a silent killer that affects 30 million Americans

An outgrowth of the obesity epidemic in the Western world and around the globe, it causes scarring and inflammation that can lead to liver cirrhosis, cardiac and lung complications, liver cancer and death.  An outgrowth of the obesity epidemic in the Western world and around the globe, it causes scarring and inflammation that can lead […]

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Ketogenic Diets as An Adjuvant Cancer Therapy

Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that are proposed to result in increased steady-state levels of mitochondrial-derived reactive oxygen species (ROS) such as O2•−and H2O2. It has also been proposed that cancer cells increase glucose and hydroperoxide metabolism to compensate for increased levels of ROS. Given this theoretical construct, it […]

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The Ketogenic Diet—A Metabolism-Based Therapy

Mitochondria are the energy-producing organelles of the cell, generating ATP via oxidative phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose. Ketone bodies generated by fatty acid oxidation can serve as alternative metabolites for aerobic energy production. The ketogenic diet, which is high in fat and low in carbohydrates, mimics the metabolic state […]

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Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice

Inappropriate eating habits such as eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running […]

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Yale-led study finds surprise link between metabolism and immunity

In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation. To better understand the role of Nucb2, a research […]

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