A Model for Weight Gain with Intensive Insulin Therapy

A major side effect of insulin treatment of diabetes is weight gain, which limits patient compliance and may pose additional health risks. Although the mechanisms responsible for this weight gain are poorly understood, it has been suggested that there may be a link to the incidence of recurrent episodes of hypoglycemia. Here we present a […]

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The Truth About Fat

National dietary guidelines were introduced in 1977 and 1983, by the United States (US) and United Kingdom (UK) governments respectively. The two specific guidelines introduced were for people to consume no more than 30% of total calories as dietary fat and no more than 10% of calories as saturated fat. It was believed at the […]

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Emotional Eating Triggers and Strategies for Control

When you understand how surrounded we are by messages connecting emotions to food—from ads conflating candy with fun to the rom-com pint of breakup ice cream to the lessons we learn within our families—it makes sense that many of us eat emotionally. This is nothing to feel ashamed of. It’s very normal to overeat or […]

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Alpha-Lipoic Acid as a Dietary Supplement

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. How do the biochemical properties of LA relate to its biological effects? […]

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Health Benefits of Nut Consumption

Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of […]

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Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women

Previous studies have been unclear about the cardiovascular risks for metabolically healthy obese individuals. Objectives This study examined the associations among metabolically healthy obese individuals and 4 different presentations of incident cardiovascular disease in a contemporary population. Methods We used linked electronic health records (1995 to 2015) in The Health Improvement Network (THIN) to assemble a cohort […]

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Neuroprotective and disease-modifying effects of the ketogenic diet

The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled clinical trials and studies in animal models […]

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How Sugar Affects the Brain

When you eat something loaded with sugar, your taste buds, your gut and your brain all take notice. This activation of your reward system is not unlike how bodies process addictive substances such as alcohol or nicotine — an overload of sugar spikes dopamine levels and leaves you craving more. Nicole Avena explains why sweets […]

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Are Schools Using Programs That Promote Weight Stigma?

Despite substantial research on school-based obesity prevention programs, it is unclear how widely they are disseminated. It is also unknown whether schools use obesity programs that inadvertently promote weight stigma or disordered weight-control behaviors. Methods In spring 2016, we distributed an online survey about school wellness programming to a simple random sample of US public […]

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Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity

A fundamental precept of the carbohydrate–insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight. METHODS: Genetic instruments of variation of insulin secretion [assessed as insulin […]

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