Green Tea Extract Prevents Obesity

Gut-derived endotoxin translocation provokes obesity by inducing TLR4/NFκB inflammation. We hypothesized that catechin-rich green tea extract (GTE) would protect against obesity-associated TLR4/NFκB inflammation by alleviating gut dysbiosis and limiting endotoxin translocation. Male C57BL/6J mice were fed a low-fat (LF) or high-fat (HF) diet containing 0% or 2% GTE for 8 weeks. At Week 7, fluorescein […]

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Diabetes, Adult Neurogenesis and Brain Remodeling

The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiologic processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also impairs brain morphology and functions such as  decreased neurogenesis (proliferation, differentiation and cell […]

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Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-Aged Adults

Question  Is high consumption of ultraprocessed food associated with an increase in overall mortality risk? Findings  In this cohort study of 44 551 French adults 45 years or older, a 10% increase in the proportion of ultraprocessed food consumption was statistically significantly associated with a 14% higher risk of all-cause mortality. Meaning  An increase in ultraprocessed food consumption may […]

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Evaluation of Chemical and Physical Changes in Different Commercial Oils during Heating

When cooking oils are exposed to heat, oil degradation occurs, and by-products are produced (free fatty acids, secondary products of oxidation, polar compounds). Some by-products of oil degradation have adverse effects on health. The smoke point of an oil is believed to be correlated with the safety and stability under heat, although technical evidence to […]

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Diabetes Self-management Education and Support in Type 2 Diabetes

Diabetes is a complex and burdensome disease that requires the person with diabetes to make numerous daily decisions regarding food, physical activity, and medications.   It also necessitates that the person be proficient in a number of self-management skills (35,75,76). In order for people to learn the skills necessary to be effective self-managers, DSME is […]

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Glucose Availability Predicts the Feeding Response to Ghrelin

Metabolic feedback from the periphery to the brain results from a dynamic physiologic fluctuation of nutrients and hormones, including glucose and fatty acids, ghrelin, leptin, and insulin. The specific interactions between humoral factors and how they influence feeding is largely unknown. We hypothesized that acute glucose availability may alter how the brain responds to ghrelin, […]

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Tobacco Industry Involvement in Children’s Sugary Drinks Market

Kim H Nguyen and colleagues examine how tobacco companies applied their knowledge of flavours, colours, and child focused marketing to develop leading children’s sugar sweetened drink brands. These techniques continue to be used by drinks companies despite industry agreement not to promote unhealthy products in this way. The BMJ: Tobacco industry involvement in children’s sugary drinks market

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Is FGF21 a Biomaker of Weight Gain?

FGF21 is a complex and multifunctional circulatory protein that clearly operates in pathways involved in metabolic regulation throughout the body. Since the impact of FGF21 on energy metabolism is not fully understood, it is now imperative to investigate the physiological effects of FGF21 on energy balance. Recent gain – or loss-of-function studies in rodent models […]

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Alzheimer’s Disease Is Associated with Dysregulation of Insulin

Brain insulin resistance is a well-recognized abnormality in Alzheimer’s disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity. Objective:This study was designed to determine whether systemic […]

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