Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet

• KD induces tissue-specific reprogramming of the circadian clock in liver and gut • KD induces an increase in liver BMAL1 chromatin recruitment and amplitude of CCGs • KD drives tissue-specific oscillation of PPARα and its target genes • Oscillation of βOHB in gut and serum parallels gut-specific cycling of H3 acetylation The circadian clock […]

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What Will Happen to Your Body If You Walk Every Day

Walking is a totally free, easy exercise that requires little effort, and benefits not only your physical but also your mental well-being. If you’re looking for a simple yet very effective way of losing weight and improving your overall health, walking is something just for you. People who are physically active throughout their life are […]

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CarbLoaded: A Culture Dying to Eat

The film traces the origins of our beliefs about healthful and unhealthful food. Experts from all over the world talk about the problems as well as short and long term solutions. Among the many experts in the film are authors like Gary Taubes, Mark Sisson, and Melanie Warner. Medical doctors such as David Perlmutter M.D., […]

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Effects of Smoking Versus Nonsmoking On Postprandial Glucose Metabolism In Heavy Smokers Compared With Nonsmokers

Epidemiological studies suggest that smoking increases the risk of type 2 diabetes. We hypothesized that smoking-derived nicotine and ensuing activation of nicotinic cholinergic receptors in the gastrointestinal tract and the autonomic nervous system would have a detrimental effect on postprandial glucose metabolism and, thus, potentially constitute a link between smoking and the development of type […]

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Oxidative Stress Inhibits Healthy Adipose Expansion

Recent studies have emphasized the association of adipose oxidative stress (Fat ROS) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivoremain unclear because no mouse model has been available in which oxidative stress is manipulated targeting adipocytes. In this research, we generated two models of […]

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