Bread and Other Edible Agents of Mental Disease

Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. Here we attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains—the world’s most abundant […]

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The Role of Magnesium in Depression Treatment

Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An […]

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Emerging Cancer Trends among Young Adults in the USA

Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 […]

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Midlife Hypertension and 20-Year Cognitive Change

Hypertension is a treatable potential cause of cognitive decline and dementia, but its greatest influence on cognition may occur in middle age. The objective of the study was to evaluate the association between midlife (48-67 years of age) hypertension and the 20-year change in cognitive performance. The Atherosclerosis Risk in Communities cohort (1990-1992 through 2011-2013) […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Exercising to Relax

How does exercise reduce stress, and can exercise really be relaxing? Rest and relaxation. It’s such a common expression that it has become a cliche. And although rest really can be relaxing, the pat phrase causes many men to overlook the fact that exercise can also be relaxing. It’s true for most forms of physical […]

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Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments

Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body […]

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The ketogenic diet as a potential treatment and prevention strategy for Alzheimer’s disease

The prevalence of Alzheimer’s disease, a chronic neurodegenerative condition, is increasing as is the need for effective treatments and preventions. The underlying pathology of Alzheimer’s is not yet fully understood, so existing research has focused on understanding the prominent features of the disease. These include amyloid plaques, which accumulate in the brains of those with […]

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Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice

Inappropriate eating habits such as eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running […]

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