Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain

We investigated whether ultra-processed foods affect energy intake in20 weight-stable adults, aged (mean±SE) 31.2±1.6y and BMI=27±1.5kg/m2. Subjects were admitted to the NIH Clinical Center and randomized to receive either ultra-processed or unprocessed diets for 2 weeks immediately followed by the alternate diet for 2 weeks. Meals were designed to be matched for presented calories, energy […]

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Changes in Energy Expenditure Resulting from Altered Body Weight

o current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effects of experimental perturbations of body weight on energy expenditure to determine whether they lead to metabolic changes and whether obese subjects and those who have never been obese respond […]

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Increasing Adiposity – Consequence or Cause of Overeating?

Ninety years ago, an editorial in JAMA questioned the prevailing approach to obesity treatment: “When we read that ‘the fat woman has the remedy in her own hands—or rather between her own teeth’ . . . there is an implication that obesity is usually merely the result of unsatisfactory dietary bookkeeping. . . [Although logic suggests that […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Exercising to Relax

How does exercise reduce stress, and can exercise really be relaxing? Rest and relaxation. It’s such a common expression that it has become a cliche. And although rest really can be relaxing, the pat phrase causes many men to overlook the fact that exercise can also be relaxing. It’s true for most forms of physical […]

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Fructose and Insulin Sensitivity in Patients with Type 2 Diabetes

The effect of dietary fructose (20% of carbohydrate calories, 45–65 g day−1 for 4 weeks) on glycaemic control, serum lipid, lipoprotein and apoprotein A‐I and A‐II concentrations and on insulin sensitivity was studied in 10 type 2 diabetic patients. The study was done in a randomized, double‐blind fashion with crystalline fructose or placebo administered evenly during […]

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Effects of Sugar on Blood Pressure and Lipids

Sugar has been suggested as a central risk factor in the development of noncommunicable diseases. We assessed the evidence of the effects of free sugars compared with complex carbohydrates on selected cardiovascular disease risk factors. DWe conducted a systematic review and meta-analysis of intervention trials to compare diets that provide a given amount of energy […]

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Emerging cancer trends among young adults in the USA

Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 […]

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What is a correct food portion?

Nutrition scientists have devised a new way of measuring out food portions – using your hands, thumbs and fists rather than a set of scales. The new guide from the British Nutrition Foundation has been created after studying portion sizes around the world and what is available in UK supermarkets. It is thought that better portion control […]

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