Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer

Tumor patients exhibit an increased peripheral demand of fatty acids and protein. Contrarily, tumors utilize glucose as their main source of energy supply. Thus, a diet supplying the cancer patient with sufficient fat and protein for his demands while restricting the carbohydrates (CHO) tumors thrive on, could be a helpful strategy in improving the patients’ […]

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Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents

The purpose for the study is to compare the effects of a low-carbohydrate (LC) diet with those of a low-fat (LF) diet on weight loss and serum lipids in overweight adolescents. The study is designed as a randomized, controlled 12-week trial. Random, nonblinded assignment of participants referred for weight management. The study group (LC) (n = […]

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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of […]

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We’re in a new age of obesity. How did it happen?

Hypotheses abound concerning the origins of the global obesity epidemic. Genetic predisposition, maternal obesity, excessive maternal weight gain, diabetes, tobacco use during pregnancy, and prenatal exposure to obesogens or endocrine disruptors have all been implicated. An international survey of more than 300 policymakers reported that more than 90% believed personal motivation was a strong or very […]

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Effects of Low-Carbohydrate and Low-Fat Diets

Low-carbohydrate diets are popular for weight loss, but their cardiovascular effects have not been well-studied, particularly in diverse populations. The objective of the study is to examine the effects of a low-carbohydrate diet compared with a low-fat diet on body weight and cardiovascular risk factors. In the study were involved 148 men and women without clinical […]

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Healthy dietary indices and risk of depressive outcomes

With depression being the psychiatric disorder incurring the largest societal costs in developed countries, there is a need to gather evidence on the role of nutrition in depression, to help develop recommendations and guide future psychiatric healthcare. The aim of this systematic review was to synthesize the link between diet quality, measured using a range […]

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Development of the Highly Processed Food Withdrawal Scale

Food addiction posits that highly processed foods may be capable of triggering addictive-like symptoms in some individuals, including withdrawal. The current study developed and assessed the psychometric properties of the first self-report measure of highly processed food withdrawal. Individuals (n = 231) aged 19-68 (51.9% female) were recruited online through Amazon Mechanical Turk and reported cutting down […]

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Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism

Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span. Our goal was to determine whether alternate-day fasting is a feasible method of dietary restriction in nonobese humans and whether it improves known biomarkers of longevity. Nonobese subjects (8 men and 8 women) fasted […]

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Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults

Alternate-day fasting has become increasingly popular, yet, to date, no long-term randomized clinical trials have evaluated its efficacy. Study has as objective  the comparison of the effects of alternate-day fasting vs daily calorie restriction on weight loss, weight maintenance, and risk indicators for cardiovascular disease. A single-center randomized clinical trial of obese adults (18 to 64 […]

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Intermittent Fasting Promotes Adipose Thermogenesis and Metabolic Homeostasis via VEGF-Mediated Alternative Activation of Macrophage

Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. […]

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