Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases?

Epidemiologic studies suggest a link between excess sugar consumption and obesity, fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus. The Journal of the American Osteopathic Association: Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases? One important pathway that may link these metabolic diseases to […]

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Energy Expenditure and Body Composition Changes after An Isocaloric Ketogenic Diet in Overweight and Obese Man

The carbohydrate–insulin model of obesity posits that habitual consumption of a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia and results in adaptive suppression of energy expenditure (EE). The American Journal of Clinical Journal: Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men Therefore, isocaloric exchange of dietary carbohydrate for fat is […]

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Eating at ‘wrong time’ affects body weight, circadian rhythms

A new high-precision feeding system for lab mice reinforces the idea that the time of day food is eaten is more critical to weight loss than the amount of calories ingested. Science Daily: Eating at ‘wrong time’ affects body weight, circadian rhythms Mice on a reduced calorie plan that ate only during their normal feeding/active cycle […]

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The Low-Carbohydrate Diet and Cardiovascular Risk Factors

Obesity is an important public health issue because of its high prevalence and concomitant increase in risk of cardiovascular diseases. PMC: The low-carbohydrate diet and cardiovascular risk factors: Evidence from epidemiologic studies Low carbohydrate diets are popular for weight loss and weight management but are not recommended in leading guidelines due to the perception that increases […]

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Ketogenic Diet and Heart Disease

Russ Scala sits down with Bill to talk about how he used the ketogenic diet to take control of his life after a near fatal heart attack. Scala Precision Health and The Institute offer cutting-edge research, metabolic testing, and advanced imaging that pushes innovative performance solutions into the hands of companies, physicians, and athletes.

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What Is A Ketogenic Diet?

The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain-function. However, if there is very little carbohydrate in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass […]

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Constrained Total Energy Expenditure and Metabolic Adaptation to Physical Activity in Adult Humans

Current obesity prevention strategies recommend increasing daily physical activity, assuming that increased activity will lead to corresponding increases in total energy expenditure and prevent or reverse energy imbalance and weight gain. Current Biology: Constrained Total Energy Expenditure and Metabolic Adaptation to Physical Activity in Adult Humans Such Additive total energy expenditure models are supported by exercise […]

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Exercise: Is More Always Better?

Animals that acquire, assimilate, and metabolize energy from food and can use these available energy sources to successfully reproduce are positioned for optimal survival. Current Biology: Exercise: Is More Always Better? Flexibility is an important feature of this biological construct that allows animals and other organisms to adjust as energy availability waxes and wanes with varying food resources and metabolic […]

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