An Evolutionary and Mechanistic Perspective on Dietary Carbohydrate Restriction in Cancer Prevention

The confluence of basic cell biochemistry, epidemiological and anthropologic evidence points to high dietary carbohydrate and the associated disruption of the glucose-insulin axis as causes of the current increase in metabolic disorders, metabolic syndrome, hypertension and cardiovascular disease. This hyperinsulinemic state likely contributes, as well, to an increased mutagenic microenvironment, with increased risk for cancer. […]

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The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

Dietary carbohydrate is the major determinant of postprandial glucose levels, and several clinical studies have shown that low-carbohydrate diets improve glycemic control. In this study, we tested the hypothesis that a diet lower in carbohydrate would lead to greater improvement in glycemic control over a 24-week period in patients with obesity and type 2 diabetes […]

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Long-term effects of a ketogenic diet in obese patients

Although various studies have examined the short-term effects of a ketogenic diet in reducing weight in obese patients, its long-term effects on various physical and biochemical parameters are not known. To determine the effects of a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated […]

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Twelve-Month Outcomes of A Randomized Trial of A Moderate-Carbohydrate Versus Very Low-Carbohydrate Diet in Overweight Adults with Type 2 Diabetes Mellitus or Prediabetes

Dietary treatment is important in management of type 2 diabetes or prediabetes, but uncertainty exists about the optimal diet. We randomized adults (n = 34) with glycated hemoglobin (HbA1c) > 6.0% and elevated body weight (BMI > 25) to a very low-carbohydrate ketogenic (LCK) diet (n = 16) or a moderate-carbohydrate, calorie-restricted, low-fat (MCCR) diet (n = 18). All participants were encouraged to be physically […]

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Robert Lustig, MD, What is Metabolic Syndrome, and Why are Children Getting It?

A grouping of health conditions associated with an increased risk for heart disease and type 2 diabetes. Conditions include hypertension, a large waist, high triglyceride levels, low HDL cholesterol levels, and above-normal blood glucose levels.

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Associations between Adipokines and Obesity-Related Cancer

The majority of breast cancers require action of oestrogens for their growth and progression. In addition, leptin in excess may also contribute to the pathogenesis of breast cancer. Vona-Davies and Rose summarises the contradictory results found in case-control studies (one of which was nested within a prospective study), with 3/10 showing positive correlations (55). More […]

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Link between diabetes and cancer risk firmly established

That diabetes and cancer are linked in some way is by no means a new idea, but it had never previously been confirmed. Now, a major new study draws a firm conclusion: diabetes raises a person’s risk of developing cancer. New research warns that the risk of cancer is sex-specific in people with diabetes, and […]

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Ketogenic Diet as a Metabolic Therapy for Mood Disorders

Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body […]

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Carbohydrates Are Killing Us

This year, more than 610,000 Americans will die from heart disease. It’s the leading cause of death for both men and women. For decades, doctors and nutritionists prescribed low-fat diets to people trying to lower their risk of heart disease. Saturated fats in meats and dairy products were thought to clog our arteries. Grains — […]

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