Roles of Hyperphagia and Hyperinsulinemia in Pathogenesis of the Disease

Nonalcoholic fatty liver disease (NAFLD) is a serious health-related condition all over the world; the number of patients is increasing in Asian countries including Japan. Better understanding of its pathophysiology is required to develop effective therapeutics, as patients may go on to develop non-alcoholic steatohepatitis and hepatocellular carcinomas. While NAFLD is believed to be associated […]

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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population

Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH). Outpatients 18 to 70 years old were recruited from Brooke Army Medical Center. All patients completed a baseline questionnaire and ultrasound. If fatty liver was […]

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Epidemic Growing of Liver Disease among United States adolescents

The objective of teh study is to assess recent trends in nonalcoholic fatty liver disease (NAFLD) prevalence among US adolescents. Cross-sectional data from 12 714 12-19 year olds (exclusions: chronic hepatitis, hepatotoxic medications) in the National Health and Examination Survey between 1988-1994 and 2007-2010 were used to estimate trends in suspected NAFLD, defined as overweight (body […]

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Sugar, Processed Food, and Obesity – Sugar Is In Everything – Robert Lustig MD

Sugar, Processed Food, & Obesity: Sugar Is In Everything – Robert Lustig, M.D. It’s increasingly hard to eat less sugar, as market shelves are filled with sugary products. In the past ten years alone, global sugar intake has risen by ten percent. In what’s not the first and surely not the last appeal of the […]

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Markers of Fatty Liver Disease Greatly Improve with a Keto Diet

Weight loss and diabetes reversal are not the only benefits of a low-carb, ketogenic diet. Markers of fatty liver disease — a silent killer — greatly improve, too. One year of comprehensive continuous care intervention (CCI) through nutritional ketosis improves glycosylated haemoglobin(HbA1c), body weight and liver enzymes among patients with type 2 diabetes (T2D). Here, […]

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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12‐week study comparing two hypocaloric diets (~1,500 kcal): a carbohydrate‐restricted diet (CRD) (%carbohydrate:fat:protein = 12:59:28) […]

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Genetically Determined Favourable Adiposity is Characterized by Lower Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such “favourable adiposity” alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined magnetic resonance imaging (MRI) data with genome-wide association […]

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KetoNutrition: From Science to Application

An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their […]

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To Fight Fatty Liver, Avoid Sugary Foods and Drinks

Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction of sugary foods and beverages is a plausible treatment. In this randomized clinical trial that included 40 adolescent boys aged 11 to 16 years with nonalcoholic fatty liver disease followed up for 8 weeks, provision of a […]

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