Saturated fats no longer the true enemy

Saturated fats are not the enemy. But processed foods are, according to a new policy statement from the Heart and Stroke Foundation of Canada. On Thursday, the foundation released a new policy statement that questions conventional wisdom about the dangers of saturated fats on the heart. Saturated fat is found naturally in red meat, dairy […]

Read More »

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in contributing to our current understanding of the potential importance of the host microbiome for neurodevelopment and behaviour. In particular, it has been repeatedly demonstrated […]

Read More »

No Significant Association with Dairy Fat Intake and Heart Disease

Controversy has emerged about the benefits compared with harms of dairy fat, including concerns over long-term effects. Previous observational studies have assessed self-reported estimates of consumption or a single biomarker measure at baseline, which may lead to suboptimal estimation of true risk. The aim of this study was to investigate prospective associations of serial measures […]

Read More »

Dietary carbohydrates: role of quality and quantity in chronic disease

Would reduction in total carbohydrate intake (currently typically 45-65% of total energy) help control body weight in general population and susceptible subgroups? What is the role of a low carbohydrate diet in prevention and treatment of metabolic syndrome and type 2 diabetes, and in management of type 1 diabetes? Does ketosis induced by severe carbohydrate […]

Read More »

Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review

Vascular calcification, a cause of cardiovascular morbidity and mortality, is an actively regulated process involving vitamin K dependent proteins (VKDPs) among others. Vitamin K is an essential micronutrient, present in plants and animal fermented products that plays an important role as a cofactor for the post-translational γ-carboxylation of glutamic acid residues in a number of […]

Read More »

Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study

Vitamin K–dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation depends on the availability of vitamin K. We examined whether dietary intake of phylloquinone (vitamin K-1) and menaquinone (vitamin K-2) were related to aortic calcification and coronary heart disease (CHD) in the population-based Rotterdam Study. The […]

Read More »

Juice Is Not Healthy

Obesity affects 40 percent of adults and 19 percent of children in the United States and accounts for more than $168 billion in health care spendingeach year. Sugary beverages are thought to be one of the major drivers of the obesity epidemic. These drinks (think soda and sports drinks) are the largest single source of added sugars for Americans and contribute, on […]

Read More »

Exercise for cognitive brain health in aging

We systematically appraised randomized controlled trials proposing exercise to influence cognition in older adults to (1) assess the methodologic quality using Cochrane criteria; (2) describe various exercise dose measures and assess their relationship with improved cognitive performance; and (3) identify consistent patterns of reported effects on cognition. There was overall good methodologic quality in all […]

Read More »

Dietary Restriction and Fasting Increase Lifespan

AMPK and DR maintain mitochondrial network homeostasis with age Mitochondrial fusion and fission are required for DR- and AMPK-mediated longevity Preserving mitochondrial homeostasis increases lifespan via fatty acid oxidation These longevity pathways require coordination between mitochondria and peroxisomes   Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic […]

Read More »