Examining the Health Effects of Fructose

In the 1990s, excessive fat consumption was commonly believed to be the main cause of obesity. High sugar consumption was often considered to be innocuous and possibly protective against obesity by displacing dietary fat. A decade later, the American Heart Association linked intake of added sugars to weight gain and recommended substantial decreases in consumption […]

Read More »

Obesity: Replacing Bias With Curiosity

Visualize a woman with obesity. Do you assume she eats all day and never gets off the couch? Picture a man with obesity. Do you think of him as lazy and unsuccessful? Are you secretly (or not so secretly) critical of those you love who have obesity? Do you yourself live with obesity, self-judgment, and shame? When we […]

Read More »

Eating Particular Diets Can Help Heal Us

Between 2016 and 2018, postdoctoral researchers in Cantley’s laboratory and mine established that this strategy worked on several mouse cancers, and on human cancers implanted into mice. By 2019, working with clinicians at Columbia, Cornell and Memorial Sloan Kettering, we hope to begin a study in humans with lymphomas, endometrial cancer and breast cancer, to […]

Read More »

Sweetening of The Global Diet

Evidence suggests that excessive intake of added sugars has adverse effects on cardiometabolic health, which is consistent with many reviews and consensus reports from WHO and other unbiased sources. 74% of products in the US food supply contain caloric or low-calorie sweeteners, or both. Of all packaged foods and beverages purchased by a nationally representative […]

Read More »

Resurgence of Diabetes-Related Nontraumatic Lower Extremity Amputation in U.S Population

The study had as objective to determine whether declining trends in lower extremity amputations have continued into the current decade. We calculated hospitalization rates for nontraumatic lower extremity amputation (NLEA) for the years 2000–2015 using nationally representative, serial cross-sectional data from the Nationwide Inpatient Sample on NLEA procedures and from the National Health Interview Survey […]

Read More »

Diabetes in Top 10 Leading Causes of Death

In 2015, the 10 leading causes of death were heart disease, cancer, chronic lower respiratory diseases, unintentional injuries, stroke, Alzheimer’s disease, diabetes, influenza and pneumonia, kidney disease, and suicide. These 10 causes of death accounted for 74% of the 2.7 million deaths in 2015. In both 1988–1994 and 2011–2014, the prevalence of diabetes was higher among non-Hispanic black and […]

Read More »

Ketogenic Diet Shows Promising Results for All Dementia Stages

Studies show a ketogenic diet can slow and even reverse symptoms of memory loss and cognitive impairment throughout all the dementia stages. You might be asking, “What is a ketogenic diet?” A ketogenic diet is a high-fat, adequate-protein, and low-carbohydrate diet that produces ketones—compounds the body can use to produce energy. Ketones have been shown in studies […]

Read More »

Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia

Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. OTo model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free […]

Read More »

Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy

The natural compound berberine has been reported to exhibit anti-diabetic activity and to improve disordered lipid metabolism. In our previous study, we found that such compounds upregulate expression of sirtuin 1—a key molecule in caloric restriction, it is, therefore, of great interest to examine the lipid-lowering activity of berberine in combination with a sirtuin 1 […]

Read More »