Diabetes in Top 10 Leading Causes of Death

In 2015, the 10 leading causes of death were heart disease, cancer, chronic lower respiratory diseases, unintentional injuries, stroke, Alzheimer’s disease, diabetes, influenza and pneumonia, kidney disease, and suicide. These 10 causes of death accounted for 74% of the 2.7 million deaths in 2015. In both 1988–1994 and 2011–2014, the prevalence of diabetes was higher among non-Hispanic black and […]

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Ketogenic Diet Shows Promising Results for All Dementia Stages

Studies show a ketogenic diet can slow and even reverse symptoms of memory loss and cognitive impairment throughout all the dementia stages. You might be asking, “What is a ketogenic diet?” A ketogenic diet is a high-fat, adequate-protein, and low-carbohydrate diet that produces ketones—compounds the body can use to produce energy. Ketones have been shown in studies […]

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Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia

Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. OTo model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free […]

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Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy

The natural compound berberine has been reported to exhibit anti-diabetic activity and to improve disordered lipid metabolism. In our previous study, we found that such compounds upregulate expression of sirtuin 1—a key molecule in caloric restriction, it is, therefore, of great interest to examine the lipid-lowering activity of berberine in combination with a sirtuin 1 […]

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Prevalence of Optimal Metabolic Health in American Adults

Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. Data from the National Health and Nutrition Examination Survey […]

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Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention

This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Methods Children and adolescents with overweight or obesity (n = 920) and a population‐based control sample […]

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Estimation of Global Insulin Use for Type 2 Diabetes, 2018–30

The amount of insulin needed to effectively treat type 2 diabetes worldwide is unknown. It also remains unclear how alternative treatment algorithms would affect insulin use and disability-adjusted life-years (DALYs) averted by insulin use, given that current access to insulin (availability and affordability) in many areas is low. The aim of this study was to […]

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Association Between Obesity and Cardiovascular Outcomes

Do mendelian randomization data show that an association exists between obesity and cardiovascular outcomes? In this systematic review and meta-analysis of nearly 1 million participants, obesity was associated with type 2 diabetes and coronary artery disease but not with stroke. Obesity may increase the risk of subsequent diabetes and may contribute to cardiovascular outcomes and […]

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Taking Steps to Better Health

Besides cardiovascular health, the established physical benefits of walking at a moderate pace (about three miles per hour) include: Lessened cancer risk Reduced mental decline, including dementia Lowered chance of heart disease Improved joint function Stronger bones Reduced risk for diabetes Energy boost The benefits of walking extend to mental perks as well. Walking increases the release of […]

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