Glucose Metabolism in Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral renal cyst formation. Publimed: Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Recent identification of signaling cascades deregulated in ADPKD has led to the initiation of several clinical trials, but an approved therapy is still lacking. Using a […]

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Insulin Action and Resistance in Obesity and Type 2 Diabetes

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of insulin, but attenuates insulin’s metabolic actions in the liver, skeletal muscle and adipose tissue. However, conflicting evidence indicates a lack of knowledge of the timing of these events during the development of obesity and diabetes, pointing to a key gap […]

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Comparison of A Low-Fat Diet to A Low-Carbohydrate Diet on Risk Factor for Diabetes and Cardiovascular Disease

40 overweight individuals were randomized to a low-carb and a low-fat diet for 10 weeks. The calories were matched between groups. Weight Loss: The low-carb group lost 7.0 kg (15.4 lbs) and the low-fat group lost 6.8 kg (14.9 lbs). The difference was not statistically significant. Conclusion: Both groups lost a similar amount of weight. […]

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How Sugar Makes You Sick

Table sugar (sucrose) consists of two bonded molecules: glucose and fructose. Inside the body, the bond is broken and glucose and fructose are released. The bloodstream picks up the glucose molecule and delivers it to any organ or muscle tissue that needs energy. The fructose molecule, however, can be metabolized only by the liver, which […]

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“Dirty Dozen” and “Clean Fifteen” Lists

The Environmental Working Group (EWG) recently released its 2017 “Dirty Dozen” and “Clean Fifteen” lists — a catalog of fruits and vegetables with the highest and lowest amounts of pesticide residue. Strawberries still top the “Dirty Dozen” list — in fact, one sample of strawberries had more than 20 different pesticides. The increased insect burden […]

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Things That Happen to Your Body When You Eat Sugar

We all know to go easy on the sweet stuff, but what actually happens to your system when you indulge? Here, eight ways sugar affects your body. Time: 8 Things That Happen to Your Body When You Eat Sugar Your brain suffers Fructose—the sugar that naturally occurs in fruit and is a component, with glucose, of […]

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Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010

Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics. These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making. The Jama Network: Postmarket Safety Events Among Novel Therapeutics Approved by the US […]

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Sugar Consumption Produces Effects Similar to Early Life Stress Exposure

Adverse early life experience is a known risk factor for psychiatric disorders. It is also known that stress influences food preference. Frontiers: Sugar Consumption Produces Effects Similar to Early Life Stress Exposure on Hippocampal Markers of Neurogenesis and Stress Response We were interested in exploring whether the choice of diet following early life stress exerts long-lasting […]

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Reversal of Diabetic Nephropathy by a Ketogenic Diet

Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. PLOS: Reversal of Diabetic Nephropathy by a Ketogenic Diet Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged […]

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