D-beta-hydroxybutyrate effects in Parkinson disease

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of the nigrostriatal dopaminergic neurons accompanied by a deficit in mitochondrial respiration. Publimed: D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes dopaminergic neurodegeneration and a mitochondrial deficit reminiscent of PD. Here we show that the infusion […]

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An Inconvenient Truth About Healthcare Prices

Diabetes patients already feel the daily health burden of their disease. However, the rising costs of their medical care are also taking a toll. While endocrinologists understand the problems and have solutions, getting those solutions implemented is the ultimate challenge. Endocrine News: Sticker Shock: An Inconvenient Truth About Healthcare Prices  Irl B. Hirsch, MD, professor of […]

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Ketone bodies mimic the life span extending properties of caloric restriction

The extension of life span by caloric restriction has been studied across species from yeast and Caenorhabditis elegans to primates. No generally accepted theory has been proposed to explain these observations. IUBMB Journals: Ketone bodies mimic the life span extending properties of caloric restriction Here, we propose that the life span extension produced by caloric […]

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Reversal of Diabetic Nephropathy by a Ketogenic Diet

Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. PLOS: Reversal of Diabetic Nephropathy by a Ketogenic Diet Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged […]

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Ketogenic Diet and Cancer

Research of the last two decades showed that chronic low-grade inflammation, elevated blood glucose and insulin levels may play role in the onset of a number of non-communicable diseases such as type 2 diabetes and some forms of cancer. Regular exercise and fasting can ameliorate high blood glucose and insulin levels as well as increase […]

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Ketogenic Diet Sensitizes Glucose Control of Hippocampal Excitability

A high-fat, low-carbohydrate ketogenic diet is an effective treatment for refractory epilepsy, yet myriad metabolic effects in vivo have not been reconciled clearly with neuronal effects. A ketogenic diet limits blood glucose, and produces ketone bodies from β-oxidation of lipids. Studies have explored changes in ketone bodies and/or glucose in the effects of the ketogenic […]

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Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder

Prenatal factors influence autism spectrum disorder (ASD) incidence in children and can increase ASD symptoms in offspring of animal models. These may include maternal immune activation (MIA) due to viral or bacterial infection during the first trimesters. Unfortunately, regardless of ASD etiology, existing drugs are poorly effective against core symptoms. For nearly a century a […]

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