Genetic Study Supports Carbohydrate-Insulin Model of Obesity

According to the Carbohydrate-Insulin Model of Obesity (CIM), the processed carbohydrates that flooded our diet during the low-fat diet craze undermine our metabolism and drive weight gain. Put simply: Processed carbohydrates — think white bread, white rice, potato products, low -fat snacks — raise insulin more than any other food, calorie for calorie. This is just Nutrition, 101. Insulin is the Miracle-Gro […]

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Man loses over 300 pounds on a low-carb diet

Tony has lost an impressive 326 lbs (148 kg) following a low-carb high-protein diet and walking. Congratulations! His weight-loss journey started in May 2016 after the wildfire in Fort McMurray. At this time, he had to use two airplane seats during the evacuation, delaying other people from getting to safety. This increased his motivation to attempt a […]

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Ketogenic diet may boost targeted cancer therapy

A very low carbohydrate, high-fat diet called the ketogenic diet may improve the effectiveness of an emerging class of cancer drugs, according to a study in mice by investigators at Weill Cornell Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian. In a study published in Nature on July 4, scientists provide a possible explanation for why the […]

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Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet

KD induces tissue-specific reprogramming of the circadian clock in liver and gut KD induces an increase in liver BMAL1 chromatin recruitment and amplitude of CCGs KD drives tissue-specific oscillation of PPARα and its target genes Oscillation of βOHB in gut and serum parallels gut-specific cycling of H3 acetylation   The circadian clock orchestrates rhythms in […]

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Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward

Fat and carbohydrate interact to potentiate reward independently of liking This is reflected in supra-additive responses in the striatum during food valuation Participants are able to estimate energy density from fat, but not carbohydrate Accurate estimation of energy density recruits a prefrontal-fusiform gyrus circuit Post-ingestive signals conveying information about the nutritive properties of food are […]

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Obesity is common, serious and costly

The prevalence of obesity was 39.8% and affected about 93.3 million of U.S. adults in 2015-2016. [Read CDC National Center for Health Statistics (NCHS) data brief PDF-603KB] Obesity-related conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. [Read guidelines] The estimated annual medical cost […]

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Continuous Remote Care Model Utilizing Nutritional Ketosis Improves Type 2 Diabetes Risk Factors in Patients with Prediabetes

Prediabetes (preT2D) is a major U.S. public health concern, as over 84 million adults are at greater risk of cardiovascular disease and progression to type 2 diabetes (T2D). Abnormal glucose, BMI, blood pressure, and blood lipids are risk factors for progression to T2D. The purpose of this single-arm prospective longitudinal investigation was to assess change […]

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Reverse and Prevent Diabetes with Dr. Brian Mowll

Type 2 Diabetes and pre-diabetes is a real threat for emotional eaters. But it can be reversed. Dr. Brian Mowll is the founder and medical director of SweetLife® Diabetes Health Centers. He coaches clients worldwide by showing them how optimize their health and metabolism, control blood sugar, and reverse type 2 diabetes using a natural, […]

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Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12-week study comparing two hypocaloric diets (approximately 1,500 kcal): a carbohydrate-restricted diet (CRD) (%carbohydrate:fat:protein = […]

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Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

Very-low-carbohydrate diets or ketogenic diets have been in use since the 1920s as a therapy for epilepsy and can, in some cases, completely remove the need for medication. From the 1960s onwards they have become widely known as one of the most common methods for obesity treatment. Recent work over the last decade or so […]

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