Comparison of Energy-Restricted Very Low-Carbohydrate and Low-Fat Diets on Weight Loss and Body Composition

The objective is to compare the effects of isocaloric, energy-restricted very low-carbohydrate ketogenic (VLCK) and low-fat (LF) diets on weight loss, body composition, trunk fat mass, and resting energy expenditure (REE) in overweight/obese men and women. Design Randomized, balanced, two diet period clinical intervention study. Subjects were prescribed two energy-restricted (-500 kcal/day) diets: a VLCK […]

Read More »

Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents

46 individuals were randomized to a low-carb or a low-fat diet for 36 weeks. Low-fat group was calorie restricted. Weight Loss: The low-carb group lost more weight and had greater decreases in BMI than the low-fat group. Conclusion: The low-carb group had greater reductions in BMI. Various biomarkers improved in both groups, but there was no significant […]

Read More »

Lack of Suppression of Circulating Free Fatty Acids and Hypercholesterolemia During Weight Loss on A LCHF Diet

Little is known about the comparative effect of weight-loss diets on metabolic profiles during dieting.  The purpose of this study was to compare the effect of a low-carbohydrate diet (≤20 g/d) with a high-carbohydrate diet (55% of total energy intake) on fasting and hourly metabolic variables during active weight loss. 32 obese adults were randomized […]

Read More »

Long-Term Effects of A Very-Low-Carbohydrate Weight Loss Diet Compared with A Low-Fat Diet

Long-term weight loss and cardiometabolic effects of a very-low-carbohydrate, high-saturated-fat diet (LC) and a high-carbohydrate, low-fat diet (LF) have not been evaluated under isocaloric conditions. 118 individuals with abdominal obesity were randomized to a low-carb or a low-fat diet for 1 year. Both diets were calorie restricted. Weight Loss: The low-carb group lost 14.5 kg (32 […]

Read More »

Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12-week study comparing two hypocaloric diets (~1,500 kcal): a carbohydrate-restricted diet (CRD) (%carbohydrate:fat:protein = 12:59:28) and a low-fat […]

Read More »

Metabolic Effects of Weight Loss on a Very-Low-Carbohydrate Diet Compared With an Isocaloric High-Carbohydrate Diet in Abdominally Obese Subjects

This study was designed to compare the effects of an energy-reduced, isocaloric very-low-carbohydrate, high-fat (VLCHF) diet and a high-carbohydrate, low-fat (HCLF) diet on weight loss and cardiovascular disease (CVD) risk outcomes. 88 individuals with abdominal obesity were randomized to a very low-carb or a low-fat diet for 24 weeks. Both diets were calorie restricted. Weight […]

Read More »

The effect of a Low-Carbohydrate, Ketogenic Diet Versus a Low-Glycemic Index Diet on Glycemic Control in Type 2 Diabetes

84 individuals with obesity and type 2 diabetes were randomized to a low-carb, ketogenic diet or a calorie restricted low-glycemic diet. The study went on for 24 weeks. Weight Loss: The low-carb group lost more weight (11.1 kg – 24.4 lbs) compared to the low-glycemic group (6.9 kg – 15.2 lbs). Conclusion: The low-carb group lost significantly […]

Read More »

A Low-Carbohydrate Diet is More Effective in Reducing Body Weight than Healthy Eating

13 diabetic and 13 non-diabetic individuals were randomized to a low-carb diet or a “healthy eating” diet that followed the Diabetes UK recommendations (a calorie restricted, low-fat diet). Study went on for 3 months. Weight Loss: The low-carb group lost 6.9 kg (15.2 lbs), compared to 2.1 kg (4.6 lbs) in the low-fat group. Conclusion: The low-carb […]

Read More »

Association of Dietary, Circulating, and Supplement Fatty Acids with Coronary Risk

This study reviewed cohort studies and randomized controlled trials on the link between fatty acids and the risk of heart disease or sudden cardiac death. The study included 49 observational studies with more than 550,000 participants, as well as 27 randomized controlled trials with more than 100,000 participants. Results: The study did not find any link […]

Read More »

Meta-Analysis of Prospective Cohort Studies Evaluating the Association of Saturated Fat with Cardiovascular Disease

This meta-analysis reviewed evidence from observational studies on the link between dietary saturated fat and risk of heart disease and stroke. The studies included a total of 347,747 participants, who were followed for 5–23 years. Results: During follow up, about 3% of participants (11,006 people) developed heart disease or stroke. Saturated fat intake was not linked […]

Read More »