Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders

An Opportunity for Prevention? As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule. Of this community sample, 10.2% and 3.2% noted insomnia and hypersomnia, respectively, at the first interview. Forty […]

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Impact of Sleep on Appetite Regulation

Sleep duration seems to play an important role in the regulation of human leptin and ghrelin levels, hunger and appetite. Differences in energy balance between sleep restriction and sleep extension do not entirely explain the differences in appetite regulation since the laboratory studies kept energy intake and activity levels constant for both bedtime conditions.Sleep loss […]

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Fasting: Awakening the Rejuvenation from Within | Valter Longo

An enlightening and provocative presentation is given by Valter Longo updating audience on the benefits of fasting for life-extension. Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences, and Director of the Longevity Institute at the University of Southern California – Davis School of Gerontology, Los Angeles. Dr. Longo’s studies […]

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Researchers Discover How Eating Feeds into the Body Clock

New research has found it is not just what you eat, but when you eat that is important, knowledge which could improve the health of shift workers and people suffering from jet lag. The MRC-funded study, published today in the journal Cell, is the first to identify insulin as a primary signal that helps communicate the […]

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Brain fuel metabolism, aging, and Alzheimer’s disease

Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer’s disease–carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede […]

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The Role of Magnesium in Depression Treatment

Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An […]

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Exercise Delivers Brain Benefits

Aerobic exercise improved executive function in healthy adults who had below-average fitness levels, found a study in Neurology. The 132 sedentary participants, ages 20 to 67 years, were randomly assigned to 6 months of either aerobic exercise (up to 75% of maximum heart rate) or stretching and toning 4 times a week. At the 24-week follow-up, executive function […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Two Type 2 Diabetes Drugs Linked to Higher Risk of Heart Disease

Are second-line antidiabetic medications (ADMs) associated with cardiovascular events among insured adult patients with type 2 diabetes who are initiating second-line therapy? This cohort study of 132 737 adults with type 2 diabetes found that glucagon-like peptide 1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium-glucose cotransporter 2 inhibitors were associated with similar cardiovascular outcomes. Sulfonylureas […]

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