Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

Obesity results in a profound perturbation of the plasma metabolome At any given BMI, abnormal metabolomes associate with different health outcomes At any given BMI, different genetic obesity risks do not change the metabolome A metabolome signature effectively tracks changes in obesity Obesity is a heterogeneous phenotype that is crudely measured by body mass index […]

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Carbotoxicity

Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as “carbotoxicity.” Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as […]

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An Engineering View of Modern Chronic Disease Prevention

Ivor Cummins BE(Chem) CEng MIEI PMP® completed a Chemical Engineering degree at UCD in 1990. He has since spent over 25 years in corporate technical leadership and management positions, and was shortlisted in 2015 as one of the top 6 of 500 applicants for “Irish Chartered Engineer of the Year”. Ivor’s focus and specialty is […]

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Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia

Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. To model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free […]

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Metabolic Syndrome Highly Prevalent Even in Very Young Kids

Over 25% of 6-year-olds had at least one risk factor in study Over a quarter of young children in a study had abnormal metabolic profiles, researchers reported. In a cohort of 212 Swedish children around 6 years old, 26% possessed at least one of the criteria for metabolic syndrome — including hypertension, dyslipidemia, insulin resistance, […]

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Forecasting Life Expectancy

Understanding potential trajectories in health and drivers of health is crucial to guiding long-term investments and policy implementation. Past work on forecasting has provided an incomplete landscape of future health scenarios, highlighting a need for a more robust modelling platform from which policy options and potential health trajectories can be assessed. This study provides a […]

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Cellular recycling process is key to longer, healthier life

Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy – the process a cell uses […]

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Current rates of diagnosed type 1 and type 2 diabetes in American adults

A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease. The study found that 8.5 percent of American adults have been diagnosed with type 2 diabetes and .5 percent with type 1 diabetes. Among those who […]

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