Association Between Ultraprocessed Food Consumption and Risk of Mortality

Question  Is high consumption of ultraprocessed food associated with an increase in overall mortality risk? Findings  In this cohort study of 44 551 French adults 45 years or older, a 10% increase in the proportion of ultraprocessed food consumption was statistically significantly associated with a 14% higher risk of all-cause mortality. Meaning  An increase in ultraprocessed food consumption may […]

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Low-carbohydrate diet in type 2 diabetes: stable improvement of bodyweight and glycemic control during 44 months follow-up

Low-carbohydrate diets, due to their potent antihyperglycemic effect, are an intuitively attractive approach to the management of obese patients with type 2 diabetes. We previously reported that a 20% carbohydrate diet was significantly superior to a 55–60% carbohydrate diet with regard to bodyweight and glycemic control in 2 groups of obese diabetes patients observed closely […]

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High Blood Sugar Can Cause Heart Disease

Type 2 diabetes can increase the risk of developing heart disease if the blood sugar condition is not controlled properly. If you have diabetes, how can you lower your risk of complications such as heart attacks and strokes? Type 2 diabetes is when the level of sugar in the blood is too high. The condition is lifelong, […]

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Should dietary fat guidelines have been introduced?

Zoë Harcombe was the first pupil from her school to graduate from Cambridge University. While studying maths and economics at this historic institution, Zoë set out to answer the million dollar question – “Why do you overeat? When all you want is to be slim?” This became the title of Zoë’s first book – published […]

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Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain

We investigated whether ultra-processed foods affect energy intake in20 weight-stable adults, aged (mean±SE) 31.2±1.6y and BMI=27±1.5kg/m2. Subjects were admitted to the NIH Clinical Center and randomized to receive either ultra-processed or unprocessed diets for 2 weeks immediately followed by the alternate diet for 2 weeks. Meals were designed to be matched for presented calories, energy […]

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Changes in Energy Expenditure Resulting from Altered Body Weight

o current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effects of experimental perturbations of body weight on energy expenditure to determine whether they lead to metabolic changes and whether obese subjects and those who have never been obese respond […]

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Increasing Adiposity – Consequence or Cause of Overeating?

Ninety years ago, an editorial in JAMA questioned the prevailing approach to obesity treatment: “When we read that ‘the fat woman has the remedy in her own hands—or rather between her own teeth’ . . . there is an implication that obesity is usually merely the result of unsatisfactory dietary bookkeeping. . . [Although logic suggests that […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Exercising to Relax

How does exercise reduce stress, and can exercise really be relaxing? Rest and relaxation. It’s such a common expression that it has become a cliche. And although rest really can be relaxing, the pat phrase causes many men to overlook the fact that exercise can also be relaxing. It’s true for most forms of physical […]

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