Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-Aged Adults

Question  Is high consumption of ultraprocessed food associated with an increase in overall mortality risk? Findings  In this cohort study of 44 551 French adults 45 years or older, a 10% increase in the proportion of ultraprocessed food consumption was statistically significantly associated with a 14% higher risk of all-cause mortality. Meaning  An increase in ultraprocessed food consumption may […]

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Evaluation of Chemical and Physical Changes in Different Commercial Oils during Heating

When cooking oils are exposed to heat, oil degradation occurs, and by-products are produced (free fatty acids, secondary products of oxidation, polar compounds). Some by-products of oil degradation have adverse effects on health. The smoke point of an oil is believed to be correlated with the safety and stability under heat, although technical evidence to […]

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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population

Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH). Outpatients 18 to 70 years old were recruited from Brooke Army Medical Center. All patients completed a baseline questionnaire and ultrasound. If fatty liver was […]

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Epidemic Growing of Liver Disease among United States adolescents

The objective of teh study is to assess recent trends in nonalcoholic fatty liver disease (NAFLD) prevalence among US adolescents. Cross-sectional data from 12 714 12-19 year olds (exclusions: chronic hepatitis, hepatotoxic medications) in the National Health and Examination Survey between 1988-1994 and 2007-2010 were used to estimate trends in suspected NAFLD, defined as overweight (body […]

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FGF21: an endocrine inhibitor of sugar and alcohol appetite.

Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic metabolic effects. Its production is induced by varied dietary imbalances in mice (including low-protein and ketogenic diets, fructose feeding, and ethanol), hinting that it might influence food preference given the role of the liver in maintaining homeostatic levels of circulating nutrients. In 2016, it […]

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Sugar, Processed Food, and Obesity – Sugar Is In Everything – Robert Lustig MD

Sugar, Processed Food, & Obesity: Sugar Is In Everything – Robert Lustig, M.D. It’s increasingly hard to eat less sugar, as market shelves are filled with sugary products. In the past ten years alone, global sugar intake has risen by ten percent. In what’s not the first and surely not the last appeal of the […]

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Markers of Fatty Liver Disease Greatly Improve with a Keto Diet

Weight loss and diabetes reversal are not the only benefits of a low-carb, ketogenic diet. Markers of fatty liver disease — a silent killer — greatly improve, too. One year of comprehensive continuous care intervention (CCI) through nutritional ketosis improves glycosylated haemoglobin(HbA1c), body weight and liver enzymes among patients with type 2 diabetes (T2D). Here, […]

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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12‐week study comparing two hypocaloric diets (~1,500 kcal): a carbohydrate‐restricted diet (CRD) (%carbohydrate:fat:protein = 12:59:28) […]

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The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m2 and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of […]

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Genetically Determined Favourable Adiposity is Characterized by Lower Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such “favourable adiposity” alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined magnetic resonance imaging (MRI) data with genome-wide association […]

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