Cellular recycling process is key to longer, healthier life

Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals. A study jointly led by Drs. Salwa Sebti and Álvaro Fernández, postdoctoral researchers in the Center for Autophagy Research, found that mice with persistently increased levels of autophagy – the process a cell uses […]

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The Critical Importance of Time Restricted Feeding in Weight Loss

There have been two main changes in dietary habits from the 1970s (before the obesity epidemic) until today. First, there was the change is what we were recommended to eat. Prior to 1970, there was no official government sanctioned dietary advice. You ate what your mother told you to eat. With the publication of the […]

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Reverse engineered approach to human longevity

Dr. Peter Attia is a health speaker, researcher, nutrition and longevity expert, and the founder of Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. His practice applies nutrition science, lipidology, four-system endocrinology, sleep physiology, stress management, and exercise physiology to minimize the risk of chronic disease onset, […]

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We’re in a new age of obesity. How did it happen?

Hypotheses abound concerning the origins of the global obesity epidemic. Genetic predisposition, maternal obesity, excessive maternal weight gain, diabetes, tobacco use during pregnancy, and prenatal exposure to obesogens or endocrine disruptors have all been implicated. An international survey of more than 300 policymakers reported that more than 90% believed personal motivation was a strong or very […]

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Development of the Highly Processed Food Withdrawal Scale

Food addiction posits that highly processed foods may be capable of triggering addictive-like symptoms in some individuals, including withdrawal. The current study developed and assessed the psychometric properties of the first self-report measure of highly processed food withdrawal. Individuals (n = 231) aged 19-68 (51.9% female) were recruited online through Amazon Mechanical Turk and reported cutting down […]

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Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism

Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span. Our goal was to determine whether alternate-day fasting is a feasible method of dietary restriction in nonobese humans and whether it improves known biomarkers of longevity. Nonobese subjects (8 men and 8 women) fasted […]

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Intermittent Fasting Promotes Adipose Thermogenesis and Metabolic Homeostasis via VEGF-Mediated Alternative Activation of Macrophage

Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. […]

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Effects of Intermittent Fasting on Health Markers in Those with Type 2 Diabetes: A Pilot Study

The aim of the study is t determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer […]

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A Link Between the Digestive System and Problems with Sleep

When we lie awake at night, unable to sleep, we usually blame stress, depression, anxiety, adrenaline or the memory of something stupid we said in 2003. But what if our guts were actually the culprit? What if the trillions of microbes sitting in our small intestines – known collectively as the microbiome or microbiota – […]

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