Markers of Fatty Liver Disease Greatly Improve with a Keto Diet

Weight loss and diabetes reversal are not the only benefits of a low-carb, ketogenic diet. Markers of fatty liver disease — a silent killer — greatly improve, too. One year of comprehensive continuous care intervention (CCI) through nutritional ketosis improves glycosylated haemoglobin(HbA1c), body weight and liver enzymes among patients with type 2 diabetes (T2D). Here, […]

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The brain-changing benefits of exercise

What’s the most transformative thing that you can do for your brain today? Exercise! says neuroscientist Wendy Suzuki. Get inspired to go to the gym as Suzuki discusses the science of how working out boosts your mood and memory — and protects your brain against neurodegenerative diseases like Alzheimer’s.

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The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

Dietary carbohydrate is the major determinant of postprandial glucose levels, and several clinical studies have shown that low-carbohydrate diets improve glycemic control. In this study, we tested the hypothesis that a diet lower in carbohydrate would lead to greater improvement in glycemic control over a 24-week period in patients with obesity and type 2 diabetes […]

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Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain

We investigated whether ultra-processed foods affect energy intake in20 weight-stable adults, aged (mean±SE) 31.2±1.6y and BMI=27±1.5kg/m2. Subjects were admitted to the NIH Clinical Center and randomized to receive either ultra-processed or unprocessed diets for 2 weeks immediately followed by the alternate diet for 2 weeks. Meals were designed to be matched for presented calories, energy […]

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Changes in Energy Expenditure Resulting from Altered Body Weight

o current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effects of experimental perturbations of body weight on energy expenditure to determine whether they lead to metabolic changes and whether obese subjects and those who have never been obese respond […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Exercising to Relax

How does exercise reduce stress, and can exercise really be relaxing? Rest and relaxation. It’s such a common expression that it has become a cliche. And although rest really can be relaxing, the pat phrase causes many men to overlook the fact that exercise can also be relaxing. It’s true for most forms of physical […]

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Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice

Inappropriate eating habits such as eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running […]

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