Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice

Inappropriate eating habits such as eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running […]

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Obesity: Replacing Bias With Curiosity

Visualize a woman with obesity. Do you assume she eats all day and never gets off the couch? Picture a man with obesity. Do you think of him as lazy and unsuccessful? Are you secretly (or not so secretly) critical of those you love who have obesity? Do you yourself live with obesity, self-judgment, and shame? When we […]

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Prevalence of Optimal Metabolic Health in American Adults

Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. Data from the National Health and Nutrition Examination Survey […]

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Dr. David Perlmutter on the Link Between Sugar and Alzheimer’s Disease

As noted by Perlmutter, even though there’s no conventional treatment for Alzheimer’s, research shows this devastating degenerative neurological disease can be effectively prevented by lowering sugar exposure, increasing exercise and improving the quality of your sleep. “The science is now completely lined up behind us, showing that our dietary choices are having a huge influence on the […]

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Metabolic Syndrome Highly Prevalent Even in Very Young Kids

Over 25% of 6-year-olds had at least one risk factor in study Over a quarter of young children in a study had abnormal metabolic profiles, researchers reported. In a cohort of 212 Swedish children around 6 years old, 26% possessed at least one of the criteria for metabolic syndrome — including hypertension, dyslipidemia, insulin resistance, […]

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We’re in a new age of obesity. How did it happen?

Hypotheses abound concerning the origins of the global obesity epidemic. Genetic predisposition, maternal obesity, excessive maternal weight gain, diabetes, tobacco use during pregnancy, and prenatal exposure to obesogens or endocrine disruptors have all been implicated. An international survey of more than 300 policymakers reported that more than 90% believed personal motivation was a strong or very […]

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Effects of Vitamin K2 on Osteoporosis

Vitamin K2 is a cofactor of γ-carboxylase, which converts the glutamic acid (Glu) residue in osteocalcin molecules to γ-carboxyglutamic acid (Gla), and is, therefore, essential for γ-carboxylation of osteocalcin. Available evidence suggests that vitamin K2 also enhances osteocalcin accumulation in the extracellular matrix of osteoblasts in vitro. Osteocalcin-knockout mice develop hyperostosis, suggesting that the Gla-containing […]

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Walk After Meals Is More Effective for Lowering Postprandial Glycaemia in Type 2 Diabetes

Regular physical activity is a cornerstone of diabetes management. We conducted a study to evaluate whether specifying the timing of walking in relation to meals enhances the benefits conferred by current physical activity guidelines. A total of 41 adults with type 2 diabetes mellitus (mean ± SD age 60 ± 9.9 years; mean diabetes duration 10 years) participated in this randomised, […]

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