The Ketogenic Diet

The ketogenic diet is a low-carbohydrate, adequate-protein, and high-fat diet with a long history of use for the treatment of intractable seizures in children. This dietary therapy has been enjoying increasing popularity in recent years, despite the availability of increasing numbers of new antiepileptic drugs and surgical treatments. The authors review the history of the […]

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Evidence for Inflammation-Associated Depression

This chapter explores the evidence supporting inflammation-associated depression. Data to date suggest a bidirectional relationship between inflammation and depression wherein one process can drive the other. A wealth of animal and clinical studies have demonstrated an association between concentrations of pro-inflammatory cytokines – specifically interleukin (IL)-1β, IL-6, and tumor necrosis factor-α – and depressive symptoms. […]

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Dietary Fat is Not a Major Determinant of Body Fat

The percentage of energy from fat in diets has been thought to be an important determinant of body fat, and several mechanisms have been proposed. Comparisons of diets and the prevalence of obesity between affluent and poor countries have been used to support this relationship, but these contrasts are seriously confounded by differences in physical […]

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What is Metabolic Syndrome Anyway?

Dr. Lustig specializes in the field of neuroendocrinology, with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes. Dr. Lustig holds a Bachelor’s in Science from MIT, a Doctorate in Medicine from Cornell University Medical College, and a Master’s […]

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Cancer Statistics, Trends, and Multiple Primary Cancer Analyses

An overview of cancer statistics and trends for selected cancers and all sites combined are given based on data from the Surveillance, Epidemiology, and End Results Program. Median age at diagnosis for all sites combined shows a 2-year increase from 1974 through 1978 to 1999 through 2003. Changes in cancer incidence rates from 1975 through […]

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Nutrition and Cancer – Time to Rethink

In 1931 Otto Warburg received the Nobel Prize for showing that cancer cells have an absolute requirement to use glucose for their energy requirements since they lack proper mitochondrial function for oxidizing fats. This suggests that nutritional factors in particular low or high carbohydrate diets might influence cancer outcomes differently. In my presentation I will […]

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The Impact of Dietary Changes in the Context of Modern Medicine

Medical talk will be around diet in the context of treatments of heart disease. Main topics to be covered: 1. Coronary stents, 2. Statins (primary and secondary prevention) 3. Communication of risk/informed consent 4. WHO figures on CVD 5. Smoking and heart disease 6. Saturated fat and heart disease 7. Tom Frieden’s CDC-health impact pyramid […]

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Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain

We investigated whether ultra-processed foods affect energy intake in 20 weight-stable adults, aged (mean ± SE) 31.2 ± 1.6 years and BMI = 27 ± 1.5 kg/m2. Subjects were admitted to the NIH Clinical Center and randomized to receive either ultra-processed or unprocessed diets for 2 weeks immediately followed by the alternate diet for 2 weeks. Meals were designed to be matched […]

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Direct Toxicity of Insulin on the Human Placenta

The objective was to study the effects of insulin and metformin on primary trophoblasts from early pregnancies.Trophoblasts from healthy patients undergoing first trimester elective termination of pregnancy and primary lung fibroblasts (IMR-90).The study cultured and treated with insulin and metformin teh primary trophoblasts and primary lung fibroblasts (IMR-90).DNA damage measured by expression of γ-H2AX with […]

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3 First Steps to Going Keto (Credit Card NOT Required)

Are you considering Keto? If so, congratulations! You are about to embark on a health journey which will yield wonderful, long-lasting health benefits. It can seem confusing at first, but it really doesn’t have to be. Instead of spending lots of money on lots of “keto” products, just relax and start here. It’s free, and […]

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