Can Ketones Compensate for Deteriorating Brain Glucose Uptake During Aging? Implications for the Risk and Treatment of Alzheimer’s Disease

Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in the disease. The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain’s main physiological alternative fuel to glucose. Three […]

Read More »

Ketone Bodies as a Therapeutic for Alzheimer’s Disease

An early feature of Alzheimer’s disease (AD) is region-specific declines in brain glucose metabolism. Unlike other tissues in the body, the brain does not efficiently metabolize fats; hence the adult human brain relies almost exclusively on glucose as an energy substrate. Therefore, inhibition of glucose metabolism can have profound effects on brain function. The hypometabolism […]

Read More »

Cardiovascular Disease Responses to a Type 2 Diabetes Care Model Including Nutritional Ketosis

Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. We […]

Read More »

A Very Low-Carbohydrate Diet Improves Gastroesophageal Reflux and Its Symptoms

Obese patients with gastroesophageal reflux disease (GERD) may experience resolution of symptoms utilizing a very low-carbohydrate diet. The mechanism of this improvement is unknown. This studied aimed to prospectively assess changes in distal esophageal acid exposure and GERD symptoms among obese adults initiating a very low-carbohydrate diet. We studied obese individuals with GERD initiating a […]

Read More »

The Role of Magnesium in Depression Treatment

Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An […]

Read More »

The Nutritional Benefits of Grass Fed Butter

Dr. Berg talks about the nutritional benefits of grass-fed butter. BENEFITS: 1. Essential fatty acids 2. Fat-soluble vitamins – K2 (takes calcium out of the soft tissues and arteries. Vitamin A is also good in the immune system, the eyes, and the skin. 3. CLA (conjugated linoleic acid) – great for cardiovascular system and weight […]

Read More »

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population

Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH). Outpatients 18 to 70 years old were recruited from Brooke Army Medical Center. All patients completed a baseline questionnaire and ultrasound. If fatty liver was […]

Read More »

Epidemic Growing of Liver Disease among United States adolescents

The objective of teh study is to assess recent trends in nonalcoholic fatty liver disease (NAFLD) prevalence among US adolescents. Cross-sectional data from 12 714 12-19 year olds (exclusions: chronic hepatitis, hepatotoxic medications) in the National Health and Examination Survey between 1988-1994 and 2007-2010 were used to estimate trends in suspected NAFLD, defined as overweight (body […]

Read More »

Exercise Delivers Brain Benefits

Aerobic exercise improved executive function in healthy adults who had below-average fitness levels, found a study in Neurology. The 132 sedentary participants, ages 20 to 67 years, were randomly assigned to 6 months of either aerobic exercise (up to 75% of maximum heart rate) or stretching and toning 4 times a week. At the 24-week follow-up, executive function […]

Read More »

High-sugar diets, type 2 diabetes and Alzheimer’s disease

Recent findings suggest that high-sugar diets can lead to cognitive impairment predisposing to neurodegenerative disorders such as Alzheimer’s disease. This article discusses metabolic derangements induced by high-fructose/sucrose diets and presents evidence for the involvement of insulin resistance in sporadic Alzheimer’s disease pathogenesis. There has been much concern regarding the role of dietary sugars(fructose/sucrose) in the development […]

Read More »