Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes

Published meta-analyses indicate significant but inconsistent incident type-2 diabetes (T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is now over a decade ago that a published meta-analysis used a predefined standard to identify valid studies. Considering valid studies only, and using random effects dose–response meta-analysis (DRM) while withdrawing […]

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The Carbohydrate-Insulin Model of Obesity

Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high–glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic […]

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Fructose as A Key Player in the Development of Fatty Liver Disease

We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver. The prevalence of nonalcoholic steatohepatitis (NASH) is 3% and 20% in nonobese and obese subjects, respectively. Obesity is a low-grade chronic inflammatory condition and obesity-related cytokines such as interleukin-6, adiponectin, leptin, and tumor necrosis factor-α may play […]

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Fasting and Its Impact on Skin Anatomy, Physiology, and Physiopathology

Skin serves as the first protective line and barrier of the body. Like many other organs, skin can be affected by several disorders in response to external factors such as pathogens, ultraviolet light, and pollution, as well as endogenous alterations related to aging and/or oxidative stress disturbance. Researchers have reported new insights into how skin […]

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Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders

An Opportunity for Prevention? As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule. Of this community sample, 10.2% and 3.2% noted insomnia and hypersomnia, respectively, at the first interview. Forty […]

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Sugar: The Bitter Truth

Watch “The Skinny on Obesity” with Dr. Lustig: http://www.uctv.tv/skinny-on-obesity Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that fructose (too much) and fiber (not enough) appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini […]

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Sugar is Metabolic Poison for Type 2 Diabetes Patients

David Unwin, Fellow of the Royal College of General Practitioners (FRCGP), and Senior Partner of the Norwood Surgery presented “Real life experiences: Weighing up the pros and cons of drugs and lifestyle choices properly before making choices” at the Swiss Re Institute’s Expert Forum on diabetes.  

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Dietary Cholesterol Promotes Repair of Demyelinated Lesions in The Adult Brain

Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in the developing CNS; however, whether cholesterol insufficiency contributes to remyelination failure in MS, is unclear. Here, we show the relationship between cholesterol, myelination and neurological parameters in mouse models of demyelination and […]

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Dr Zoe Harcombe – Nutritional Nuggets to Combat Conventional Dietary Guidelines

Thermodynamics – what the laws actually say; how they have been misapplied to weight loss; the thermic effect of macro nutrients (the work of Jequier 2002, Feinan and Fine2005) and the isocaloric advantage this gives. • The origin of the calorie formula; the fact that 1lb does not equal 3,500 calories and what it could […]

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