Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson’s disease

Highlights• The CBD treatment decreases hyperalgesia and allodynia in experimental parkinsonism. • The inverse agonist of the CB1 receptor prevents the antinociceptive effect of CBD. • FAAH inhibitor or TRPV1 antagonist potentiates the CBD antinociceptive effect. Abstract Medications that improve pain threshold can be useful in the pharmacotherapy of Parkinson’s disease (PD). Pain is a […]

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Chronic Kidney Disease and CBD

Cannabidiol could improve the lives of those with kidney disease by multiple pathways as well as reducing difficult symptoms like pain. Other kidney damaging pharmaceuticals can be avoided. Working closely with Pro Health Advisor renal dietitians they have stopped and even reversed CKD in many clients by using diet as medicine and combining with CBD. […]

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Prolonged Cannabidiol Treatment Lacks on Detrimental Effects on Memory, Motor Performance and Anxiety

The Cannabis plant contains more than 100 currently known phytocannabinoids. Regarding the rising consumption of the non-psychotropic phytocannabinoid cannabidiol (CBD) in people’s everyday life (e.g., beauty products, food and beverages), the importance of studies on the influence of CBD on healthy humans and rodents is evident. Therefore, the behavioral profile of CBD was investigated with […]

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Chronic Kidney disease and CBD

Cannabidiol could improve the lives of those with kidney disease by multiple pathways as well as reducing difficult symptoms like pain. Other kidney damaging pharmaceuticals can be avoided. Working closely with Pro Health Advisor renal dietitians they have stopped and even reversed CKD in many clients by using diet as medicine and combining with CBD. […]

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Things to Know About CBD

Cannabidiol (CBD) seems to be everywhere these days. It’s in food, beverages, cosmetics and supplements. Derived from both hemp and marijuana plants, CBD does not get its users high like tetrahydrocannabinol (THC). It does, however, have other possible health benefits as an anti-inflammatory and is popular as a pain reliever. While it seems to be […]

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Care and Feeding of the Endocannabinoid System

The “classic” endocannabinoid (eCB) system includes the cannabinoid receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes. An emerging literature documents the “eCB deficiency syndrome” as an etiology in migraine, fibromyalgia, irritable bowel syndrome, psychological disorders, and other conditions. We performed a systematic review of clinical interventions that enhance […]

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Effects of non-euphoric plant cannabinoids on muscle quality and performance

Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration. Moreover, the associated impairment of autophagy leads to the accumulation of damaged intracellular organelles that greatly contribute to the aggravation of muscle damage. We explored the possibility of using non-euphoric compounds present in Cannabis sativa, including cannabidiol (CBD), […]

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How Effective Is CBD?

An interesting study just reported surveyed 2,409 online volunteers who reported using CBD mostly for pain, anxiety, and depression. 36% felt CBD was very effective alone for their condition while only 4.3% did not get benefit. This suggests 95% of individuals could benefit from CBD therapy from a quality product. What’s in your medicine cabinet? […]

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Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances

There remains debate regarding the impact of cannabis on neuropsychiatric disorders. Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of cannabis, on heroin self-administration and drug-seeking behavior using an experimental rat model. CBD (5–20 mg/kg) did not alter stable intake of heroin self-administration, extinction behavior, or drug seeking induced by a heroin […]

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