Disease-Causing Effects of High Carbohydrate Diets

Whilst evidence accumulates that high carbohydrate diets are associated with increased rates of obesity and diabetes, there is growing evidence that a range of other conditions including dementia and cancer may also have their origins in high carbohydrate diets. In this presentation I will present the scientific evidence as it currently is, linking high carbohydrate […]

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Targeting Metabolism with A Ketogenic Diet During the Treatment of Glioblastoma Multiforme

Retrospective data suggests that low serum glucose levels during the treatment of glioblastoma multiforme (GBM) may improve clinical outcomes. As such, many patients are implementing a ketogenic diet (KD) in order to decrease serum glucose flux while simultaneously elevating circulating ketones during radiation therapy and chemotherapy for the treatment of GBM. With IRB approval, a […]

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Calories, Carbohydrates, and Cancer Therapy

Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. Intriguingly, many of these mechanisms utilize the same molecular pathways that are altered through calorie and/or carbohydrate restriction. Furthermore, poorer prognosis in cancer patients who display a glycolytic phenotype characterized by […]

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Consumption of Trans Fatty Acids is Related to Inflammation

Trans fatty acid intake has been associated with a higher risk of cardiovascular disease. The relation is explained only partially by the adverse effect of these fatty acids on the lipid profile. We examined whether trans fatty acid intake could also affect biomarkers of inflammation and endothelial dysfunction including C-reactive protein (CRP), interleukin-6 (IL-6), soluble […]

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High Metastaticgastric and Breast Cancer Cells Consume Oleic Acid in an AMPK Dependent Manner

Gastric cancer and breast cancer have a clear tendency toward metastasis and invasion to the microenvironment predominantly composed of adipocytes. Oleic acid is an abundant monounsaturated fatty acid that releases from adipocytes and impinges on different energy metabolism responses. The effect and underlying mechanisms of oleic acid on highly metastatic cancer cells are not completely […]

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What is Metabolic Syndrome Anyway?

Dr. Lustig specializes in the field of neuroendocrinology, with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes. Dr. Lustig holds a Bachelor’s in Science from MIT, a Doctorate in Medicine from Cornell University Medical College, and a Master’s […]

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Cancer Statistics, Trends, and Multiple Primary Cancer Analyses

An overview of cancer statistics and trends for selected cancers and all sites combined are given based on data from the Surveillance, Epidemiology, and End Results Program. Median age at diagnosis for all sites combined shows a 2-year increase from 1974 through 1978 to 1999 through 2003. Changes in cancer incidence rates from 1975 through […]

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Nutrition and Cancer – Time to Rethink

In 1931 Otto Warburg received the Nobel Prize for showing that cancer cells have an absolute requirement to use glucose for their energy requirements since they lack proper mitochondrial function for oxidizing fats. This suggests that nutritional factors in particular low or high carbohydrate diets might influence cancer outcomes differently. In my presentation I will […]

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Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-Aged Adults

Question  Is high consumption of ultraprocessed food associated with an increase in overall mortality risk? Findings  In this cohort study of 44 551 French adults 45 years or older, a 10% increase in the proportion of ultraprocessed food consumption was statistically significantly associated with a 14% higher risk of all-cause mortality. Meaning  An increase in ultraprocessed food consumption may […]

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