KetoNutrition: From Science to Application

An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their […]

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Circadian Hormonal Inputs to Regulate Fat Cell Differentiation

Circadian adipogenic stimuli are rejected by the adipocyte differentiation system This circadian filtering requires fast and slow positive feedback to PPARG Loss of circadian glucocorticoid oscillations in mice increases fat mass Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising […]

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Exercising to Relax

How does exercise reduce stress, and can exercise really be relaxing? Rest and relaxation. It’s such a common expression that it has become a cliche. And although rest really can be relaxing, the pat phrase causes many men to overlook the fact that exercise can also be relaxing. It’s true for most forms of physical […]

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Average 10-year-old has eaten 18 years’ worth of sugar

The average 10-year-old has consumed as much sugar in their lifetime as the recommended limit for an 18-year-old, according to Public Health England (PHE), which is warning of serious implications for obesity and health. Children are consuming the equivalent of eight excess sugar cubes a day, or 2,800 a year, says PHE, which has launched a new […]

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Children eat three times as much sugar as they should

The average child has eaten their entire childhood sugar allowance by the age of ten, according to health chiefs. Figures published today by Public Health England (PHE) estimate that young children are eating almost three times as much sugar as they should, the equivalent of about eight cubes too many a day. Parents have been […]

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The Ketogenic Diet—A Metabolism-Based Therapy

Mitochondria are the energy-producing organelles of the cell, generating ATP via oxidative phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose. Ketone bodies generated by fatty acid oxidation can serve as alternative metabolites for aerobic energy production. The ketogenic diet, which is high in fat and low in carbohydrates, mimics the metabolic state […]

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Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments

Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body […]

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