Neuroinflammation and Psychiatric Illness

Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases, neuroimmunological abnormalities occur in classical psychiatric disorders (for example, major depressive, […]

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Prolonged Cannabidiol Treatment Lacks on Detrimental Effects on Memory, Motor Performance and Anxiety

The Cannabis plant contains more than 100 currently known phytocannabinoids. Regarding the rising consumption of the non-psychotropic phytocannabinoid cannabidiol (CBD) in people’s everyday life (e.g., beauty products, food and beverages), the importance of studies on the influence of CBD on healthy humans and rodents is evident. Therefore, the behavioral profile of CBD was investigated with […]

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Diabetes, Adult Neurogenesis and Brain Remodeling

The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiologic processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also impairs brain morphology and functions such as  decreased neurogenesis (proliferation, differentiation and cell […]

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Can Ketones Compensate for Deteriorating Brain Glucose Uptake During Aging? Implications for the Risk and Treatment of Alzheimer’s Disease

Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in the disease. The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain’s main physiological alternative fuel to glucose. Three […]

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Exercise Delivers Brain Benefits

Aerobic exercise improved executive function in healthy adults who had below-average fitness levels, found a study in Neurology. The 132 sedentary participants, ages 20 to 67 years, were randomly assigned to 6 months of either aerobic exercise (up to 75% of maximum heart rate) or stretching and toning 4 times a week. At the 24-week follow-up, executive function […]

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Children eat three times as much sugar as they should

The average child has eaten their entire childhood sugar allowance by the age of ten, according to health chiefs. Figures published today by Public Health England (PHE) estimate that young children are eating almost three times as much sugar as they should, the equivalent of about eight cubes too many a day. Parents have been […]

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Extra-Virgin Olive Oil Preserves Memory and Protects Brain Against Alzheimer’s

The Mediterranean diet, rich in plant-based foods, is associated with a variety of health benefits, including a lower incidence of dementia. Now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) have identified a specific ingredient that protects against cognitive decline: extra-virgin olive oil, a major component of the Mediterranean diet. In […]

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New Research Suggests Link Between Diabetes and Brain Function

A study of older people in the UK suggests people with diabetes lose cognitive ability faster than people with normal blood sugar control. The findings, published in Diabetologia, was led by researchers at Imperial College London. They studied more than 5,000 people over the age of 50 and measured their cognitive decline over a 10 year […]

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Ketogenic Diet as a Metabolic Therapy for Mood Disorders

Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body […]

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The Ketogenic Diet for Type II Bipolar Disorder

Successful mood stabilizing treatments reduce intracellular sodium in an activity-dependent manner. This can also be achieved with acidification of the blood, as is the case with the ketogenic diet. Two women with type II bipolar disorder were able to maintain ketosis for prolonged periods of time (2 and 3 years, respectively). Both experienced mood stabilization […]

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