Diabetes, Adult Neurogenesis and Brain Remodeling

The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiologic processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also impairs brain morphology and functions such as  decreased neurogenesis (proliferation, differentiation and cell […]

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Brain fuel metabolism, aging, and Alzheimer’s disease

Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer’s disease–carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede […]

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Can Ketones Compensate for Deteriorating Brain Glucose Uptake During Aging? Implications for the Risk and Treatment of Alzheimer’s Disease

Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in the disease. The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain’s main physiological alternative fuel to glucose. Three […]

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The Role of Magnesium in Depression Treatment

Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An […]

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Exercise Delivers Brain Benefits

Aerobic exercise improved executive function in healthy adults who had below-average fitness levels, found a study in Neurology. The 132 sedentary participants, ages 20 to 67 years, were randomly assigned to 6 months of either aerobic exercise (up to 75% of maximum heart rate) or stretching and toning 4 times a week. At the 24-week follow-up, executive function […]

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How Does the Ketogenic Diet Work?

The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can also have antiepileptogenic properties and can eventually have a role in treating other neurologic and nonneurologic conditions. Despite being nearly a century old, identifying the molecular underpinnings of the ketogenic diet has been challenging. However, recent studies provide experimental evidence […]

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The brain-changing benefits of exercise

What’s the most transformative thing that you can do for your brain today? Exercise! says neuroscientist Wendy Suzuki. Get inspired to go to the gym as Suzuki discusses the science of how working out boosts your mood and memory — and protects your brain against neurodegenerative diseases like Alzheimer’s.

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Extra-Virgin Olive Oil Preserves Memory and Protects Brain Against Alzheimer’s

The Mediterranean diet, rich in plant-based foods, is associated with a variety of health benefits, including a lower incidence of dementia. Now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) have identified a specific ingredient that protects against cognitive decline: extra-virgin olive oil, a major component of the Mediterranean diet. In […]

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New Research Suggests Link Between Diabetes and Brain Function

A study of older people in the UK suggests people with diabetes lose cognitive ability faster than people with normal blood sugar control. The findings, published in Diabetologia, was led by researchers at Imperial College London. They studied more than 5,000 people over the age of 50 and measured their cognitive decline over a 10 year […]

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