Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a)

Lipoprotein(a), a variant of LDL carrying the adhesive glycoprotein apo(a), is a leading risk factor for cardiovascular disease. Lipoprotein(a) (Lp(a)) is found in humans and subhuman primates but rarely in lower mammals. Better understanding of the evolutionary advantage of this molecule should elucidate its physiological role. We developed a new mouse model with two characteristics […]

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High cholesterol may protect against infections and atherosclerosis

According to the modified ‘response to injury’ hypothesis of atherogenesis, there are at least two pathways leading to the inflammatory and proliferative lesions of the arterial intima. The first involves monocyte and platelet interaction induced by hypercholesterolaemia. The second pathway involves direct stimulation of the endothelium by a number of factors, including smoking, the metabolic consequences […]

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The Impact of Dietary Changes in the Context of Modern Medicine

Medical talk will be around diet in the context of treatments of heart disease. Main topics to be covered: 1. Coronary stents, 2. Statins (primary and secondary prevention) 3. Communication of risk/informed consent 4. WHO figures on CVD 5. Smoking and heart disease 6. Saturated fat and heart disease 7. Tom Frieden’s CDC-health impact pyramid […]

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Brain fuel metabolism, aging, and Alzheimer’s disease

Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer’s disease–carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede […]

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Health Effects of Oxidized Heated Oils

The purpose of this report is to alert the foodservice industry, particularly the fast‐food industry, of an emerging health issue. Considerable evidence has accumulated over the past two decades that heated cooking oils, especially polyunsaturated oils, may pose several types of health risks to consumers of fried foods and even people working near deep fat […]

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The Straight Dope on Cholesterol

Cholesterol is one of the most misunderstood molecules in the human body. Much like fire, it can be an essential tool for life, if used properly, or a destructive force if allowed to run amok. In this presentation, Peter Attia will explain how the body creates, moves, and utilizes this vital molecule and how what […]

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Why Cholesterol is Good for You

Dr. Terry Wahls is a professor of medicine at the University of Iowa where she conducts clinical research on the use of diet and lifestyle to treat brain-related problems. She has also worked at the VA for many years in the traumatic brain injury clinic and was the director of the therapeutic lifestyle clinic. In […]

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Combined Treatment with Vitamin K2 and Bisphosphonate in Postmenopausal Women with Osteoporosis

Vitamin K2, as well as bisphosphonates, such as etidronate, alendronate, and risedronate, is widely used in the treatment with osteoporosis in Japan. Etidronate increases the lumbar bone mineral density (BMD), and prevents new vertebral fractures, in patients with osteoporosis, while alendronate and risedronate increase the lumbar and femoral neck BMDs, and prevent new vertebral and […]

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