The Effects of Keto Diet on Inflammation

The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease. The main activity of the ketogenic diet has been related to improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to […]

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Brain fuel metabolism, aging, and Alzheimer’s disease

Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer’s disease–carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede […]

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Keto Made Simple

The rapid rise in popularity in Keto Diets has created misconceptions that can make it harder to lose weight, and even cause weight gain. In this talk, Dr. Westman will give examples from the Duke and HEAL Clinics on what can lead people astray, and practical advice on how to correct these misconception.

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Can Ketones Compensate for Deteriorating Brain Glucose Uptake During Aging? Implications for the Risk and Treatment of Alzheimer’s Disease

Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in the disease. The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain’s main physiological alternative fuel to glucose. Three […]

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Ketone Bodies as a Therapeutic for Alzheimer’s Disease

An early feature of Alzheimer’s disease (AD) is region-specific declines in brain glucose metabolism. Unlike other tissues in the body, the brain does not efficiently metabolize fats; hence the adult human brain relies almost exclusively on glucose as an energy substrate. Therefore, inhibition of glucose metabolism can have profound effects on brain function. The hypometabolism […]

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Exercise Delivers Brain Benefits

Aerobic exercise improved executive function in healthy adults who had below-average fitness levels, found a study in Neurology. The 132 sedentary participants, ages 20 to 67 years, were randomly assigned to 6 months of either aerobic exercise (up to 75% of maximum heart rate) or stretching and toning 4 times a week. At the 24-week follow-up, executive function […]

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High-sugar diets, type 2 diabetes and Alzheimer’s disease

Recent findings suggest that high-sugar diets can lead to cognitive impairment predisposing to neurodegenerative disorders such as Alzheimer’s disease. This article discusses metabolic derangements induced by high-fructose/sucrose diets and presents evidence for the involvement of insulin resistance in sporadic Alzheimer’s disease pathogenesis. There has been much concern regarding the role of dietary sugars(fructose/sucrose) in the development […]

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Reduced Risk of Dementia in Elderly Tied to Higher Cholesterol Levels

Total cholesterol and cognition associations differ in studies at different outcome ages. Some associations of cholesterol with cognition diminish as outcome age increases. In the oldest-old, some relationships reverse from younger elderly samples. Studies seeking protection should focus on good cognition despite high risk. Some associations of high total cholesterol with dementia risk diminish as […]

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Canola Oil Linked to Worsened Memory and Learning Ability

In recent years consumption of canola oil has increased due to lower cost compared with olive oil and the perception that it shares its health benefits. However, no data are available on the effect of canola oil intake on Alzheimer’s disease (AD) pathogenesis. Herein, we investigated the effect of chronic daily consumption of canola oil […]

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