The case for low carbohydrate diets in diabetes management

A low fat, high carbohydrate diet in combination with regular exercise is the traditional recommendation for treating diabetes. Compliance with these lifestyle modifications is less than satisfactory, however, and a high carbohydrate diet raises postprandial plasma glucose and insulin secretion, thereby increasing risk of CVD, hypertension, dyslipidemia, obesity and diabetes. Moreover, the current epidemic of […]

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A Randomized Trial of a Low-Carbohydrate Diet for Obesity

Despite the popularity of the low-carbohydrate, high-protein, high-fat (Atkins) diet, no randomized, controlled trials have evaluated its efficacy. We conducted a one-year, multicenter, controlled trial involving 63 obese men and women who were randomly assigned to either a low-carbohydrate, high-protein, high-fat diet or a low-calorie, high-carbohydrate, low-fat (conventional) diet. Professional contact was minimal to replicate […]

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Sugar, Processed Food, and Obesity – Sugar Is In Everything – Robert Lustig MD

Sugar, Processed Food, & Obesity: Sugar Is In Everything – Robert Lustig, M.D. It’s increasingly hard to eat less sugar, as market shelves are filled with sugary products. In the past ten years alone, global sugar intake has risen by ten percent. In what’s not the first and surely not the last appeal of the […]

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Dr. Ted Naiman – ‘Insulin Resistance’

Dr. Ted Naiman graduated from the Loma Linda University School of Medicine in 1997. He is a board-certified family medicine physician who practices at the Virginia Mason Medical Center in Seattle, Washington. Dr. Naiman first learned about low-carb diets when he was an intern and heard about it from a patient who reversed the ill […]

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Recent origin and evolution of obesity-income correlation across the United States

From a gene-culture evolutionary perspective, the recent rise in obesity rates around the Developed world is unprecedented; perhaps the most rapid population-scale shift in human phenotype ever to occur. Focusing on the recent rise of obesity and diabetes in the United States, we consider the predictions of human behavioral ecology (HBE) versus the predictions of […]

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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element. We specifically tested the idea with a 12‐week study comparing two hypocaloric diets (~1,500 kcal): a carbohydrate‐restricted diet (CRD) (%carbohydrate:fat:protein = 12:59:28) […]

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The Ketogenic Diet: Adolescents Can Do It, Too

The purpose of the study is to determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. A retrospective study of 45 patients, aged 12–19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty‐seven patients were from The Johns Hopkins Medical Institutions; eight were […]

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Added Sugars Drive Nutrient and Energy Deficit in Obesity

Obesity has traditionally been thought of as a state of caloric imbalance, where the intake of calories exceeds the expenditure or ‘burning’ of calories. However, a more nuanced appreciation for the complex biochemistry and physiology of cellular energy generation suggests that obesity is a state of hormonal imbalance causing increased shunting of food energy into […]

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Genetically Determined Favourable Adiposity is Characterized by Lower Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such “favourable adiposity” alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined magnetic resonance imaging (MRI) data with genome-wide association […]

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